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Lions vs 49ers Prediction & NFL Odds For Week 17

ByUSA Wager

ABC will televise this week 17 NFC matchup between the Lions and 49ers, which kicks off at 8:15 ET. The Lions are favored on the road with a point spread of -3.5 and a money line of -196. The 49ers, the home underdog, have a money line of +164. The over/under line is set at 50.5 points for this game at Levi’s Stadium in Santa Clara, CA.

Prediction at a Glance for 49ers vs Lions

  • We have the 49ers winning this one by a score of 25 to 19
  • Not only do we have the 49ers winning straight-up, we have them covering the spread at +3.5
  • We see this game finishing below the line of 50.5 points

Betting Odds & Lines for this Game

  • Spread: Lions -3.5 | 49ers +3.5
  • Total: 50.5
  • MoneyLine: Lions -196 | 49ers +164

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Lions vs. 49ers Prediction: MoneyLine

Jared Goff has been on a tear over the past three games, culminating in a 336-yard, 3-touchdown performance in week 16 against the Bears, where he posted a passer rating of 136. In week 15, he threw for 494 yards and 5 touchdowns without an interception, and in week 14, he had 283 yards and 3 touchdowns. Jameson Williams led the team with 143 receiving yards in week 16, while Jahmyr Gibbs rushed for 109 yards on 23 carries.

Heading into week 17, the Lions are 3rd in our offensive power rankings. They lead the NFL in scoring, averaging 32.9 points per game, and are 2nd in passing yards per game with 264.7. Detroit ranks 5th in 3rd-down conversions, with a 46.7% success rate, but they are last in the league in red zone conversion percentage.

Heading into week 17, the 49ers are 16th in the NFL in scoring, averaging 22.1 points per game. They rank 8th in total offense, with 365.7 yards per game, and 7th in passing yards, with 235.7 per game, despite being 21st in passing attempts. San Francisco is 10th in rushing, averaging 130 yards per game on the ground, and they rank 10th in 3rd-down conversions.

In week 16, Brock Purdy threw for 313 yards and 2 touchdowns, with 1 interception, against the Dolphins. George Kittle led the team with 8 catches for 106 yards. The 49ers scored 7 points in the 4th quarter after being shut out in the 1st and 3rd quarters.

  • Free MoneyLine Prediction 49ers +164 (Bet Now)

Lions vs. 49ers Prediction: Total

In their 34-17 win over the Bears, the Lions’ defense gave up 323 passing yards on 26 completions. Chicago was forced into just 17 rushing attempts and gained only 59 yards on the ground. The Lions allowed two passing touchdowns and 382 total yards, but they limited the Bears to a 20% conversion rate on third down.

Detroit’s defense also came up with two sacks in the game and had a positive differential in both QB hits and tackles for loss.

In their 29-17 loss to the Dolphins, the 49ers’ defense struggled to stop the run, giving up 166 rushing yards on just 30 attempts, including a 5.5 yards per attempt average. They also allowed 381 total yards and failed to record a sack, while their opponents had five more quarterback hits than they did.

Against the pass, the 49ers gave up 215 yards, with Miami completing 64.7% of their passes. San Francisco’s defense also allowed the Dolphins to convert on 33.3% of their third down attempts.

  • Free MoneyLine Prediction UNDER 50.5 (Bet Now)

Lions vs. 49ers Prediction: Spread

At 13-2, the Lions sit atop our NFL power rankings and have a 76.3% chance of winning the NFC North. They bounced back from a week 15 loss to the Bills with a 34-17 win over the Bears in week 16. Detroit was a 6.5-point favorite and covered the spread, bringing their ATS record to 10-4-1.

Detroit’s O/U record is 8-6-1, with the over hitting in three straight games. Their games have averaged 52.8 points this season, compared to an average line of 50.1.

  • Over their last three games, the Lions have gone 2-1 straight up. However, they have only gone 1-1-1 vs. the spread over this stretch. Their over-under record in these three games was 3-0.
  • Detroit has played well in their previous 5 road games, going 5-0 straight up. In this stretch, they averaged 27 points per game while allowing 17. The team also performed well vs the spread at 4-1.

Heading into week 17, the 49ers sit 9th in our NFL power rankings despite their 6-9 record and two-game losing streak. San Francisco ranks 4th in the NFC West with a 1-4 division record and is 4-6 in conference play. After a 38-13 win over the Bears in week 14, the 49ers have dropped two straight, including a 12-point loss to the Dolphins in week 16. They were 1.5-point favorites in that game but couldn’t cover the spread, bringing their ATS record to 5-10 this season.

With the 49ers out of playoff contention, they’ll look to end their losing streak at home against the Lions in week 17. San Francisco is 4-4 at home this season and 2-5 on the road. Their average scoring margin is -1.2 points per game, and their O/U record is 8-7, with an average of 45.3 points in their games.

  • Through their last three regular season contests, San Francisco has a record of 1-2. Their record vs the spread sits at 1-2 in these matchups, while posting a 1-2 over-under mark.
  • When looking at their past five home matchups, San Francisco has an ATS record of 1-4 while averaging 19 per game. The team went 2-3 overall in these games.
  • Free Spread Prediction 49ers +3.5 (Bet Now)

Lions vs. 49ers Pick: 49ers Moneyline (+164)

Our pick vs. the spread is to take the 49ers to cover as home underdogs in this week 17 matchup between the 49ers and Lions. The point spread line has the 49ers at -3.5, and we have them winning by a score of 27-22.

For this week 17 matchup, we are leaning towards taking the under, with the line sitting at 50.5 points. Our projections have these teams finishing with 49 combined points.

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