Titans vs Colts Prediction & NFL Odds For Week 16

The Colts are favored at -4.5 as they host the Titans at Lucas Oil Stadium on Sunday, December 22nd at 1:00 ET. The Colts’ money line odds are -218, and the over/under line is set at 42.5 points. This week 16 AFC South matchup is being televised on CBS, and the Titans’ money line odds are +180. The Colts and Titans both need to add their records.

Prediction at a Glance for Colts vs Titans

• We have the Colts winning this one by a score of 23 to 16
• Not only do we have the Colts winning straight-up, we have them covering the spread at -4.5
• We see this game finishing below the line of 42.5 points

Betting Odds & Lines for this Game

• Spread: Titans +4.5 | Colts -4.5
• Total: 42.5
• MoneyLine: Titans +180 | Colts -218

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Titans vs. Colts Prediction: MoneyLine

Heading into week 16, the Titans rank 30th in our offensive power rankings. They are 24th in the NFL in points per game (18.1) and 26th in passing yards per game (190.6) and total yards per game (301). Tennessee averages 31.4 passing attempts per game (19th) and 26.1 rushing attempts per game (18th), with 110.4 rushing yards per game (18th). They have been efficient in the red zone, converting 39.5% of their attempts, which ranks 8th in the league.

In week 15, the Titans scored 27 points against the Bengals, with 13 coming in the 4th quarter. Mason Rudolph threw for 209 yards (21/26) and 2 touchdowns, with one interception. Tony Pollard had 45 rushing yards on 17 carries, and Tyjae Spears led the team with 87 receiving yards on 6 catches.

Heading into week 16, the Colts are 28th in our offensive power rankings. They rank 20th in both points per game (20) and yards per game (311.4). Indianapolis is 23rd in passing attempts and 27th in passing yards per game (190.4). On the ground, they rank 13th in rushing attempts and 12th in rushing yards per game (120.9). The Colts are 24th in the NFL in 3rd-down conversions, with a 35.8% success rate, but they are 12th in red zone conversion percentage.

Anthony Richardson struggled in week 15, posting a passer rating of 36 after going 17/38 for 161 yards and 2 interceptions. Jonathan Taylor rushed for 107 yards on 22 carries, while Michael Pittman Jr. had 6 catches for 58 yards. The Colts were shut out in the 2nd half against the Broncos and converted only 4 of 15 3rd-down attempts.

• Free MoneyLine Prediction Colts -218 (Bet Now)

Titans vs. Colts Prediction: Total

In the Titans’ 37-27 loss to the Bengals, their defense allowed Cincinnati to convert on 76.9% of their third down attempts. The Titans gave up 269 passing yards, with the Bengals completing 70.3% of their passes. Despite allowing just 101 rushing yards, the Titans gave up three passing touchdowns and managed only one sack.

Tennessee’s defense did come up with two interceptions and held the Bengals to 3.9 yards per rushing attempt. However, the Titans allowed 370 total yards and two of the Bengals’ three touchdowns came through the air.

In their 31-13 loss to the Broncos, the Colts’ defense allowed just 121 passing yards but gave up three passing touchdowns. They struggled to pressure the quarterback, with just one sack and losing the QB hit differential by -9. Despite their struggles against the pass, the Colts’ defense intercepted three passes in the game.

The Colts’ run defense was solid, allowing just 72 yards on 27 attempts. However, they still gave up 193 total yards and 31 points, with Denver finding success through the air with big plays for touchdowns. On third down, the Colts allowed the Broncos to convert 35.3% of their chances.

• Free MoneyLine Prediction UNDER 42.5 (Bet Now)

Titans vs. Colts Prediction: Spread

With a 3-11 record, the Titans sit 4th in the AFC South, and our power rankings have them 28th heading into week 16. Tennessee has lost three straight games, including a 37-27 defeat to the Bengals in week 15. They were unable to cover the spread as 6-point underdogs, and the 64 combined points easily went over the 46-point line.

Against the spread, the Titans are just 2-12, with an average scoring margin of -8.9 points per game. They are 0-4 as favorites and 2-8 as underdogs. Their O/U record is 8-5-1, with their games averaging 45.2 points compared to a 41.2-point line.

• Across Tennessee’s last three regular season games, their record sits at 0-3. Their record vs the spread sits at 0-3 in these matchups, while posting a 2-1 over-under mark.
• Through their last five road contests, the Titans offense has averaged 18 points per game while allowing an average of 36. Tennessee posted an overall record of 1-4 while going 1-4 ATS.

Heading into week 16, the Colts sit at 6-8, putting them 2nd in the AFC South. After a narrow win over the Patriots in week 13, Indy couldn’t keep the momentum going, falling 31-13 to the Broncos in week 15. They were 4.5-point underdogs in that game but couldn’t cover, bringing their ATS record to 8-6. The Colts have now dropped 3 straight against the spread.

Our power rankings have the Colts 23rd this week, and they have an 8.7% chance of making the playoffs. Their O/U record is 7-7, with the over hitting in their last two games. Indy’s games have averaged 43.5 points this season, compared to an average line of 44.4.

• The Colts have gone 1-2 over their last three regular season games. Their record against the spread in this stretch is 1-2 to go along with an over-under mark of 1-2.
• Through their last five home games, Indianapolis has an ATS record of just 2-3. However, their overall record was 2-3 while averaging 19 points per game.

• Free Spread Prediction Colts -4.5 (Bet Now)

Titans vs. Colts Pick: Colts -4.5

Our pick to cover the spread is to take the Colts at home, as they are currently sitting at -4.5 point favorites in this week 16 matchup against the Titans. We have the Colts winning by a score of 25-16.

For the over/under, we have a slight lean towards the under, with a projected combined score of 41 points and the O/U line sitting at 42.5 points.