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Rams vs 49ers Prediction & NFL Odds For Week 15

ByUSA Wager

The 49ers are favored at -144 on the money line as they host the Rams at 8:15 ET on Thursday, December 12th at Levi’s Stadium in Santa Clara, CA. The Rams are +123 on the money line, and the over/under line is 48.5 points, with the 49ers favored by -2.5 points. This week 15 NFC West matchup is being televised by AMZN.

Prediction at a Glance for 49ers vs Rams

  • We have the 49ers winning this one by a score of 22 to 19
  • Not only do we have the 49ers winning straight-up, we have them covering the spread at -2.5
  • We see this game finishing below the line of 48.5 points

Betting Odds & Lines for this Game

  • Spread: Rams +2.5 | 49ers -2.5
  • Total: 48.5
  • MoneyLine: Rams +123 | 49ers -144

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Rams vs. 49ers Prediction: MoneyLine

Heading into week 15, the Rams are 11th in our offensive power rankings. They rank 14th in the NFL in points per game (22.9) and 15th in yards per game (340.7). Los Angeles is 9th in passing yards per game with 237.7, coming on 33.8 attempts per game (12th). On the ground, they average 103 rushing yards per game, which ranks 25th, on 26 attempts per game. The Rams are 20th in the league in 3rd-down conversion percentage (36.7%) and 23rd in red zone conversion percentage, despite ranking 5th in red zone attempts. They have struggled in the 1st quarter, ranking 24th in points per game.

Matthew Stafford has been on fire over his last three games, posting passer ratings of 104, 110, and 132 in week 14. Against the Bills, he threw for 320 yards and 2 touchdowns on 23/30 passing without an interception. Stafford’s top target, Puka Nacua, had 12 catches for 162 yards in week 14, while Kyren Williams rushed for 87 yards and 2 touchdowns on 29 carries.

After struggling in weeks 12 and 13, the 49ers bounced back in week 14 with a 38-13 win over the Bears. Brock Purdy threw for 325 yards and 2 touchdowns, completing 20 of 25 passes. George Kittle had 6 catches for 151 yards, and Isaac Guerendo rushed for 78 yards and 2 touchdowns. San Francisco scored 14 points in both the first and fourth quarters and converted 5 of 6 red zone attempts.

Heading into week 15, the 49ers rank 12th in our offensive power rankings. They are 11th in the NFL in scoring, averaging 23.7 points per game, and 4th in total yards with 378.5 per game. Despite ranking 27th in passing attempts, they are 7th in passing yards and 7th in rushing yards per game.

  • Free MoneyLine Prediction 49ers -144 (Bet Now)

Rams vs. 49ers Prediction: Total

In the Rams’ 44-42 win over the Bills, their defense allowed 342 passing yards and 103 rushing yards on just 17 attempts. Buffalo had a chance to win at the end with a field goal but missed. The Rams’ defense gave up 9.2 yards per attempt, and the Bills had three passing touchdowns. Los Angeles didn’t record a sack in the game and had a tough time on third downs, allowing the Bills to convert 55.6% of their third down attempts. Despite this, the Rams still came out on top.

The 49ers’ defense was dominant in their most recent game, a 38-13 win over the Bears. They allowed just 94 passing yards and held Chicago to 18 completions. Despite giving up two passing touchdowns, the 49ers’ defense recorded seven sacks and limited the Bears to 3.2 yards per attempt on the ground. Chicago managed just 68 rushing yards on 21 attempts.

San Francisco’s pass rush was relentless, winning the QB hit differential by +4 and forcing the Bears into 7-of-17 on third down. Although the Bears found the end zone twice through the air, the 49ers forced them to a 75% completion percentage on their passes.

  • Free MoneyLine Prediction UNDER 48.5 (Bet Now)

Rams vs. 49ers Prediction: Spread

After snapping a two-game losing streak with a week 13 win over the Saints, the Rams made it two in a row by defeating the Bills 44-42 in week 14. Los Angeles entered the game as 3.5-point underdogs but came away with the win, improving their record to 7-6. The Rams are now 2nd in the NFC West with a 2-1 division record and rank 14th in our NFL power rankings heading into week 15.

We currently give the Rams a 34.5% chance of making the playoffs and a 32.3% chance of winning the NFC West. They have a scoring margin of -2.6 points per game and are 6-7 against the spread this season. Their O/U record is 7-6, with their games averaging 48.5 points (47.2 O/U line).

  • Through their last three games, the Rams have a record of 2-1. This also includes going 2-1 ATS and an over-under mark of 2-1.
  • The Rams are 3-2 ATS in their last road games and 3-2 straight-up.

After three straight losses, the 49ers got back on track in week 14 with a 38-13 win over the Bears, improving to 6-7. San Francisco entered the game as 3-point favorites and covered the spread, and the 51 combined points went over the 43.5-point line. The win puts the 49ers 8th in our power rankings, but they have just a 10.7% chance of making the playoffs.

San Francisco is 5-8 against the spread this season, with an average scoring margin of 0. They are 5-6 ATS as favorites and 0-2 as underdogs. Their O/U record is 7-6, with their games averaging 47.4 points compared to a 46.3-point line.

  • The 49ers have posted a 2-1 record in their previous three games. In these games, they have a 2-1 record vs the spread and an over-under mark of 2-1.
  • In their last five games at home, the 49ers have a straight up record of 2-3 while going 1-4 vs the spread. The team’s offense averaged 20 points per game in these contests.
  • Free Spread Prediction 49ers -2.5 (Bet Now)

Rams vs. 49ers Pick: 49ers -2.5

Our pick vs. the spread is to take the 49ers to cover as home favorites in this week 15 matchup against the Rams. Currently, the point spread lines have the 49ers at -2.5 favorites, and we have them winning by a score of 26-21.

For the over/under, with the line sitting at 48.5 points, we are leaning towards the under with a projected combined score of 47 points.

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