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Lions vs Colts Prediction & NFL Odds For Week 12

ByUSA Wager

On the money line, the Lions are -365 as they get set to take on the Colts at 1:00 ET on Sunday, November 24th. The game, being played at Lucas Oil Stadium in Indianapolis, will be aired on FOX. The Colts are the heavy underdogs at +290 on the money line, with the Lions favored by -7.5 points. The over/under line is set at 51 points.

Prediction at a Glance for Colts vs Lions

  • We have the Lions winning this one by a score of 34 to 22
  • Not only do we have the Lions winning straight-up, we have them covering the spread at -7.5
  • Look for this game to go over the line of 51 points

Betting Odds & Lines for this Game

  • Spread: Lions -7.5 | Colts +7.5
  • Total: 51
  • MoneyLine: Lions -365 | Colts +290

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Lions vs. Colts Prediction: MoneyLine

Heading into week 12, the Lions are 2nd in our offensive power rankings and lead the NFL in scoring with 33.6 points per game. They rank 3rd in total yards per game (394.7) and 6th in passing yards, despite being 26th in pass attempts. Jared Goff is coming off a 412-yard, 4-touchdown performance in week 11, posting a perfect passer rating of 158.3.

Detroit has leaned on the run game, ranking 3rd in both rushing attempts and yards per game. David Montgomery rushed for 75 yards and 2 touchdowns on 15 carries in week 11, while Amon-Ra St. Brown had 11 catches for 161 yards and 2 touchdowns.

Heading into week 12, the Colts sit 24th in our offensive power rankings, averaging 21.5 points per game, which ranks 18th in the league. They are 21st in passing yards per game, with 202.2, and 20th in passing attempts. On the ground, they rank 16th in rushing yards per game, with 118.5, on 26.5 attempts per game. Indianapolis ranks 19th in the NFL in 3rd-down conversion percentage and 17th in red zone conversion rate, despite being 8th in red zone attempts.

In week 11, the Colts scored 12 points in the 4th quarter to beat the Jets, with Anthony Richardson throwing for 272 yards and a touchdown. Jonathan Taylor had 57 yards on 24 carries, and Josh Downs led the team with 5 catches for 84 yards. Indianapolis converted 6 of 15 3rd-down attempts and scored on 3 of 4 red zone trips.

  • Free MoneyLine Prediction Lions -365 (Bet Now)

Lions vs. Colts Prediction: Total

The Lions’ defense was dominant in their most recent game, giving up just 170 yards to the Jaguars in a 52-6 win. Jacksonville managed only 41 yards on 17 rushing attempts, averaging just 2.4 yards per attempt. Detroit defended the pass well, allowing only 129 yards through the air and not giving up any passing touchdowns.

They held Jacksonville to a 58.6% completion percentage and allowed the Jaguars to convert on just 20% of their third down attempts. The Lions also came away with one interception and had one sack in the game.

In their 28-27 win over the Jets, the Colts’ defense gave up 162 passing yards on 22 completions. They were tough against the run, allowing just 91 yards on 20 attempts. Despite this, the Colts did allow two passing touchdowns. The defense also recorded three sacks and held the Jets to a 30.8% conversion rate on third down.

The Jets completed 75.9% of their passes against the Colts, but overall, Indianapolis gave up just 253 total yards in the game. The Colts’ defense will look to tighten up in the secondary and prevent giving up big plays in their next outing.

  • Free Total Prediction OVER 51 (Bet Now)

Lions vs. Colts Prediction: Spread

With eight straight wins, the Lions sit atop our NFL power rankings and have a 99.9% chance of making the playoffs. They are 9-1, including a 5-0 record on the road, and lead the NFC North with a 2-0 division record. Detroit also holds a 6-1 record in conference games.

The Lions are 8-2 against the spread, with an average scoring margin of +15.9 points per game. In week 11, they easily covered a 14-point spread by beating the Jaguars 52-6. Their O/U record is 5-4-1 this season, with their games averaging 51.3 points.

  • Detroit has put together a record of 3-0 over their past three games. In addition, their ATS record over this stretch is 2-1 while posting a 1-1-1 over-under mark.
  • When looking at their past five road matchups, Detroit has an ATS record of 4-1 while averaging 29 per game. The team went 5-0 overall in these games.

After three straight losses, the Colts got back in the win column with a 28-27 victory over the Jets in week 11. This improved their record to 5-6 and keeps them 2nd in the AFC South. Indy has a -1.3 scoring margin this season, but they are 8-3 against the spread, including a 6-2 mark as underdogs.

Heading into week 12, our power rankings have the Colts 25th, and we give them a 32.6% chance of making the playoffs. They have an O/U record of 5-6, with the over hitting in their last two games.

  • Spanning across their last three games, Indianapolis have gone 2-1. Their strong play has also resulted in an ATS mark of 2-1 (last 3). They had an over/under mark of 2-1 in those same games.
  • In their last five home games, Indianapolis has averaged 23 points per game while allowing 25. The team’s record in this stretch was 2-3 while going 4-1.
  • Free Spread Prediction Lions -7.5 (Bet Now)

Lions vs. Colts Pick: Lions -7.5

Our point spread pick for this week 12 matchup between the Lions and Colts is to take the Lions to cover as road favorites. Currently, the Lions are sitting at -7.5 point favorites, and we have them winning by a score of 31-22.

As for an over/under pick, with the line at 51 points, we are leaning towards taking the over with a projected combined score of 53 points.

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