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Lions vs Cardinals Prediction & NFL Odds For Week 3

ByUSA Wager

FOX will broadcast the week three matchup between the Lions and Cardinals from State Farm Stadium in Glendale, AZ. The game is set for 4:25 ET on Sunday, September 22nd. The Lions are favored on the road with a -3 point spread and money line odds of -149. The over/under line is at 52.5 points.

Prediction at a Glance for Cardinals vs Lions

  • We have the Cardinals winning this one by a score of 26 to 25
  • Not only do we have the Cardinals winning straight-up, we have them covering the spread at +3
  • We see this game finishing below the line of 52.5 points

Betting Odds & Lines for this Game

  • Spread: Lions -3 | Cardinals +3
  • Total: 52.5
  • MoneyLine: Lions -149 | Cardinals +125

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Lions vs. Cardinals Prediction: MoneyLine

The Lions’ offense, led by Jared Goff, put up 324 yards through the air on 56 attempts in their 20-16 loss to the Buccaneers. Goff completed 34 passes, finishing with a passer rating of 61 and throwing two interceptions. Detroit had 26 first downs and 139 rushing yards on 27 attempts, averaging 5.1 yards per attempt.

Jahmyr Gibbs was their top rusher with 84 yards, averaging 6.5 yards per attempt, and Amon-Ra St. Brown led the receiving corps with 119 yards on 11 catches. The Lions struggled to finish drives, failing to score a touchdown and going 0-for-1 in the red zone.

The Cardinals’ offense was firing on all cylinders in their 41-10 win over the Rams, with Kyler Murray completing 17 of 21 passes for 266 yards and three touchdowns. Arizona’s running game was also impressive, racking up 231 yards on 40 attempts. Murray didn’t take a sack in the game and finished with a passer rating of 158.

James Conner had a big game on the ground, rushing for 122 yards on 21 carries and scoring once. Marvin Harrison Jr. was the top receiver for Arizona, with 130 yards receiving and two touchdowns, including a 60-yard reception. The Cardinals finished with 24 first downs and converted 63.6% of their third down attempts.

  • Free MoneyLine Prediction Cardinals +125 (Bet Now)

Lions vs. Cardinals Prediction: Total

In the Lions’ 20-16 loss to the Buccaneers, Detroit’s defense gave up just 216 yards, with Tampa Bay managing only 70 rushing yards on 23 attempts. The Lions’ defense was strong against the pass, allowing just 146 yards through the air. They also recorded five sacks and held the Buccaneers to a 20% third-down conversion rate.

Despite their strong defensive performance, the Lions still came up short. They did force one interception and limited Tampa Bay to a 63.2% completion rate. The Lions’ offense struggled, scoring just 16 points, which included one defensive touchdown.

In their most recent game, the Cardinals’ defense was dominant, coming away with five sacks and holding the Rams to just 53 rushing yards on 20 attempts. Arizona’s secondary limited the Rams to 192 passing yards in their 41-10 win, not allowing a touchdown through the air. The defense also excelled on third downs, allowing only an 18.2% conversion rate.

The Cardinals’ defensive front was disruptive, winning the battle in both quarterback hits and tackles for loss. Overall, the Rams managed just 245 total yards against Arizona’s defense, while the unit as a whole allowed a 70.4% completion rate to the Rams.

  • Free MoneyLine Prediction UNDER 52.5 (Bet Now)

Lions vs. Cardinals Prediction: Spread

Despite being 7.5 point favorites, the Lions lost to the Buccaneers 20-16, dropping their record to 1-1. Detroit fell behind early, with Tampa Bay leading 6-3 after the first quarter. The Lions added a field goal in the 2nd quarter, trailing 13-6 at halftime, and then had a strong 3rd quarter, taking a 16-13 lead before Baker Mayfield’s 11-yard touchdown put the Buccaneers back in front.

Jake Bates’ field goal in the 3rd quarter and a 1-yard touchdown run from David Montgomery gave the Lions a brief lead in the 3rd quarter. The game had a total of 36 points, falling short of the over/under line of 52 points.

  • Detroit has put together a record of 1-2 in their last three games (regular season). Against the spread, they have a strong mark of 2-1 along with an over-under record of 1-2.
  • In their last five road games, Detroit has averaged 25 points per game while allowing 26. The team’s record in this stretch was 2-3 while going 4-1.

The Cardinals picked up a 41-10 win over the Rams, evening their record at 1-1. Arizona dominated from the start, leading 14-0 after the first quarter and 24-3 at halftime. They extended their lead to 34-10 heading into the 4th quarter and finished off the game with a 31-point victory. The over/under line was 47.5 points, and the combined score was 51 points.

Kyler Murray threw two early touchdowns to Marvin Harrison Jr., and James Conner found the endzone twice in the 3rd quarter. Matt Prater added a 57-yard field goal in the 3rd quarter. The Cardinals’ only touchdown in the 4th quarter was a 41-yard run by Emari Demercado.

  • Through their last three regular season contests, Arizona has a record of 1-2. This also includes going 2-1 ATS, and posting an over-under record of 2-1.
  • Across their last five home contests, Arizona has a 4-1 record vs the spread. Their overall mark in these games was 2-3, while averaging 23 points per game.
  • Free Spread Prediction Cardinals +3 (Bet Now)

Lions vs. Cardinals Pick: Cardinals Moneyline (+125)

Our pick against the spread is to take the Cardinals to cover as home underdogs in this week three matchup against the Lions. Right now, the point spread lines have the Cardinals at +3, and our projected final score is 25-22 in favor of Arizona.

For this game, we have a point spread pick and an over/under pick. Our pick vs. the spread is to take the Cardinals to cover as home underdogs. As for the over/under, with the line sitting at 52.5 points, we like the under, projecting a combined score of 47 points.

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