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Jaguars vs Bills Prediction & NFL Odds For Week 3

The Bills are favored on the money line at -257 as they host the Jaguars on Monday, September 23rd at 7:30 ET on ESPN. Buffalo is favored by -5.5 points in this week three matchup, and the over/under line is set at 45.5 points. The Jaguars’ record and the Bills’ record are not yet available.

Prediction at a Glance for Bills vs Jaguars

  • We have the Bills winning this one by a score of 28 to 25
  • Even though we like the Bills to win, our ATS pick is to take the Jaguars at +5.5
  • Look for this game to go over the line of 45.5 points

Betting Odds & Lines for this Game

  • Spread: Jaguars +5.5 | Bills -5.5
  • Total: 45.5
  • MoneyLine: Jaguars +210 | Bills -257

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Jaguars vs. Bills Prediction: MoneyLine

The Jaguars’ offense struggled to sustain drives in their 18-13 loss to the Browns, as they managed just 18 first downs despite putting up 127 rushing yards on 21 attempts. Trevor Lawrence and the passing game struggled, with Lawrence going 14/30 for 196 yards, and the team as a whole finished with a completion percentage of 46.7% and four sacks.

Travis Etienne Jr. led the team with 52 rushing yards, averaging 4 yards per attempt and scoring one rushing touchdown. Brian Thomas Jr. was the top receiver, with two catches for 94 yards, including a 66-yard reception. Lawrence also added 45 rushing yards on two attempts.

Josh Allen completed 13 of 19 passes for 139 yards and one touchdown in Buffalo’s 31-10 win over the Dolphins. The Bills’ offense didn’t pick up many first downs, with just 13, and they finished with 108 yards on 26 attempts. Allen wasn’t sacked in the game and had a passer rating of 107.

James Cook led the rushing attack with 78 yards on 11 carries, including two touchdowns and a 49-yard run. Khalil Shakir was Buffalo’s top receiver, with 54 yards on five catches. The Bills’ offense will look to be more efficient in moving the chains in their next game.

  • Free MoneyLine Prediction Bills -257 (Bet Now)

Jaguars vs. Bills Prediction: Total

In the Jaguars’ 18-13 loss to the Browns, Jacksonville’s defense gave up just 172 passing yards. The Jaguars struggled to stop the run, allowing 125 yards on 29 attempts. Despite this, they held Cleveland to 18 points and limited them to a 14.3% third-down conversion rate.

Jacksonville’s defense recorded two sacks and held the Browns to a 64.7% completion rate. The Jaguars’ offense managed just 297 yards in the game, contributing to their overall struggle in this one.

In their most recent game, the Bills’ defense played well, coming up with three interceptions and allowing just 212 passing yards in their 31-10 win over the Dolphins. Buffalo’s run defense was also solid, holding Miami to 139 yards on 34 attempts. The Bills gave up 351 total yards in the game and allowed the Dolphins to convert on 46.7% of their third down attempts.

Buffalo’s defense recorded two sacks in the game and limited Miami to a 5.4 yards per attempt in the passing game. Despite this, the Bills did allow one passing touchdown. Buffalo also had the upper hand in tackles for loss and quarterback hits.

  • Free Total Prediction OVER 45.5 (Bet Now)

Jaguars vs. Bills Prediction: Spread

The Jaguars fell to the Browns 18-13, dropping their record to 0-2 for the season. Jacksonville was favored by -3 at home but lost straight-up and against the spread. The game saw a late Jaguars score in the 4th quarter, but they were unable to complete the comeback.

Jacksonville fell behind early, with the Browns taking a 7-0 lead after a Deshaun Watson touchdown. The Jaguars added a field goal in the 2nd quarter and closed the gap to 10-6 with a Trevor Lawrence touchdown run. After the Browns added a field goal in the 3rd, Lawrence connected with Brian Thomas Jr. for a touchdown in the 3rd quarter, and the Jaguars added a field goal in the 4th, but it wasn’t enough to pull off the comeback.

  • Across Jacksonville’s last three regular season games, their record sits at 0-3. In these contests, the team went just 1-2 against the spread, while going 1-2 on the over-under.
  • When looking at their past five road matchups, Jacksonville has an ATS record of 2-3 while averaging 20 per game. The team went 1-4 overall in these games.

The Bills are now 2-0 after a 31-10 win over the Dolphins. Buffalo went into the game as +2.5 point underdogs and easily covered the spread with their 21-point victory. The game finished with a combined total of 41 points, falling short of the over/under line of 49 points.

Buffalo and Miami were tied at 7 after the 1st quarter, but the Bills took control in the 2nd quarter, outscoring the Dolphins 24-3. The Bills’ offense was led by Josh Allen, who threw for two touchdowns, including a 34-yard touchdown pass to Ty Johnson. Buffalo’s defense also intercepted Tua Tagovailoa in the 3rd quarter to prevent any chance of a Dolphins comeback.

  • Over their last three games, the Bills have gone 2-1 straight up. Across these games, they have put together an ATS mark of 1-2 as well as an over-under record of 3-0.
  • In their last five home games, Buffalo has averaged 26 points per game while allowing 20. The team’s record in this stretch was 4-1 while going 3-2 vs. the spread.
  • Free Spread Prediction Jaguars +5.5 (Bet Now)

Jaguars vs. Bills Pick: Jaguars +5.5

With the point spread sitting at 5.5 in favor of the Jaguars, our pick vs. the spread is to take the Bills to cover as home favorites. However, we actually have the Jaguars as our pick to cover at the current line.

For the over/under, we are leaning towards taking the over, with a projected combined score of 48 points compared to the current line of 45.5 points.

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