Chiefs vs Panthers Prediction & NFL Odds For Week 12

The Panthers are +440 on the money line as they host the Chiefs at 1:00 ET on Sunday, November 24th at Bank of America Stadium in Charlotte, NC. The Chiefs are favored by -11 on the road, and the current over/under line is 41.5 points. This non-conference matchup is being televised on CBS. The Chiefs need to add their record, and the Panthers need to add their record.

Prediction at a Glance for Panthers vs Chiefs

• We have the Chiefs winning this one by a score of 29 to 16
• Not only do we have the Chiefs winning straight-up, we have them covering the spread at -11
• Look for this game to go over the line of 41.5 points

Betting Odds & Lines for this Game

• Spread: Chiefs -11 | Panthers +11
• Total: 41.5
• MoneyLine: Chiefs -607 | Panthers +440

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Chiefs vs. Panthers Prediction: MoneyLine

Patrick Mahomes threw for 196 yards and 3 touchdowns in week 11, completing 23 of 33 passes, but he also had 2 interceptions. Kareem Hunt had 14 carries for 60 yards, and Xavier Worthy led the team with 61 receiving yards on 4 catches. The Chiefs scored 7 points in the 4th quarter after being shut out in the 1st and 3rd quarters, converting 50% of their 3rd downs and going 3/3 in the red zone.

Heading into week 12, Kansas City ranks 10th in passing yards per game (226.5) and 23rd in rushing yards per game (111.4). They are 10th in the NFL in scoring, averaging 24 points per game, and lead the league in 3rd-down conversion percentage (51.9%). However, they rank 25th in 1st-quarter scoring.

Heading into week 12, the Panthers sit 29th in our offensive power rankings. They are 27th in the NFL in scoring, averaging 16.7 points per game, and rank 32nd in total yards per game with 280.7. Carolina is 15th in passing attempts but 29th in passing yards per game, averaging 170.7. On the ground, they are 24th in both rushing attempts and yards per game, with an average of 110 rushing yards. The Panthers rank 27th in 3rd-down conversions but are 8th in red zone conversion percentage, despite being 15th in red zone attempts.

Rookie QB Bryce Young posted a passer rating of 86 in week 10, throwing for 126 yards and a touchdown without an interception. Chuba Hubbard led the rushing attack with 153 yards on 28 carries, while Jalen Coker had 3 catches for 41 yards. Carolina scored 17 points in regulation against the Giants, with 7 points in both the 1st and 3rd quarters.

• Free MoneyLine Prediction Chiefs -607 (Bet Now)

Chiefs vs. Panthers Prediction: Total

In their 30-21 loss to the Bills, the Chiefs’ defense allowed Buffalo to convert on 60% of their third down attempts. The Chiefs gave up 262 passing yards and 104 yards on 27 completions. Despite this, they did manage to force one interception. Kansas City’s defense was unable to generate much pressure, as they didn’t record any sacks and lost the quarterback hit differential by -3.

In the Panthers’ 20-17 overtime win over the Giants, their defense allowed 342 total yards, with New York finding some success in the running game, gaining 167 yards on 34 attempts. However, Carolina’s defense was tough against the pass, allowing just 175 yards through the air and not giving up any passing touchdowns. They also came up with two interceptions and held the Giants to a 59.5% completion percentage.

Despite the Giants converting 46.7% of their third down attempts, the Panthers’ defense made key plays when needed. Carolina also recorded two sacks, and their players were able to get 1 more QB hit than the Giants.

• Free Total Prediction OVER 41.5 (Bet Now)

Chiefs vs. Panthers Prediction: Spread

Despite their week 11 loss to the Bills, the Chiefs remain atop the AFC with a 9-1 record. Before this, they had won nine straight, including a 16-14 victory over the Broncos in week 10. Kansas City was favored by 7 points but couldn’t cover, ending a three-game ATS losing streak. They are 4-5-1 against the spread this season.

Heading into week 12, the Chiefs have a 93.3% chance of winning the AFC West and are 4th in our power rankings. Their O/U record stands at 5-5, with their games averaging 43.1 points (O/U line: 45).

• Kansas City will look to keep things rolling as they have put together a mark of 2-1 over their past three games. Across these games, they have put together an ATS mark of 0-3 as well as an over-under record of 2-1.
• In their last five games away from home, the Chiefs have a straight up record of 4-1 while going 2-2-1 vs the spread. The team’s offense averaged 23 points per game in these contests.

After snapping a six-game losing streak with back-to-back wins, the Panthers are now 3-7 heading into week 12. Carolina followed up their 23-22 victory over the Saints in week 9 with a 20-17 win over the Giants in week 10. They were underdogs in both games, but covered the spread each time, including a +6.5 line against New York.

Despite their two-game winning streak, the Panthers have just a 0.3% chance of making the playoffs, according to our projections. They currently rank 30th in our power rankings and sit last in the NFC South at 1-2 in division play. Their O/U record is 7-3 this season, with their games averaging 47.7 points compared to a 42.8-point line.

• Carolina will look to keep things rolling as they have put together a mark of 2-1 over their past three games. In these games, they have a 2-1 record vs the spread and an over-under mark of 2-1.
• Across the Panthers last five home games, the team averaged 15 points per game while allowing 34. Their record vs the spread in these contests was 1-4, while going 1-4 straight-up.

• Free Spread Prediction Chiefs -11 (Bet Now)

Chiefs vs. Panthers Pick: Chiefs -11

Our pick vs. the spread is to take the Chiefs to cover as 11-point road favorites in this week 12 matchup between the Chiefs and Panthers. Our final score prediction is 27-15 in favor of the Chiefs.

For the over/under line, with the line sitting at 41.5 points, we have these teams combining for 42 points, making the over our best bet.