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Cardinals vs Rams Prediction & NFL Odds For Week 17

ByUSA Wager

The Rams are favored on the money line at -273 as they host the Cardinals in a week 17 NFC West matchup. The game is being played at SoFi Stadium in Inglewood, CA, and the over/under line is set at 48 points. On the point spread, the Rams are -6-point favorites. This one is set to kick off at 8:00 ET on Saturday, December 28th, with coverage on NFLN.

Prediction at a Glance for Rams vs Cardinals

  • We have the Rams winning this one by a score of 23 to 22
  • Even though we like the Rams to win, our ATS pick is to take the Cardinals at +6
  • We see this game finishing below the line of 48 points

Betting Odds & Lines for this Game

  • Spread: Cardinals +6 | Rams -6
  • Total: 48
  • MoneyLine: Cardinals +222 | Rams -273

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Cardinals vs. Rams Prediction: MoneyLine

Heading into week 17, the Cardinals sit 12th in our offensive power rankings. They are 14th in the NFL in scoring, averaging 22.9 points per game, and 11th in total yards with 353.4 per game. Arizona ranks 20th in passing yards, with 207.6 per game, and 5th in rushing, averaging 145.8 yards per game on the ground. They are 8th in the league in 3rd-down conversions, with a 43.2% success rate.

In week 16, the Cardinals scored 30 points in a loss to the Panthers, with 17 of those coming in the 2nd quarter. Kyler Murray threw for 202 yards, completing 20 of 32 passes, with 1 touchdown and 1 interception. James Conner rushed for 117 yards on 15 carries and also led the team in receiving, with 4 catches for 49 yards.

Heading into week 17, the Rams are 11th in our offensive power rankings, averaging 21.9 points per game (17th) and 331.5 yards per game (15th). They rank 13th in passing yards with 224 per game and 20th in rushing, with 107.5 yards per game. Los Angeles is 23rd in the NFL in 3rd-down conversions (36.6%) and 22nd in red zone conversion rate, despite being 6th in red zone attempts. They have struggled early in games, ranking 23rd in 1st quarter scoring.

Matthew Stafford threw for 110 yards (14/19) with 1 touchdown and 1 interception in week 16 against the Jets. Kyren Williams rushed for 122 yards on 23 carries, while Puka Nacua had 8 catches for 56 yards. The Rams scored 13 points in the 4th quarter and converted 50% of their 3rd downs (5/10) and 2 of 5 red zone attempts.

  • Free MoneyLine Prediction Rams -273 (Bet Now)

Cardinals vs. Rams Prediction: Total

In their 36-30 overtime loss to the Panthers, the Cardinals’ defense gave up 243 rushing yards on just 36 attempts, with Carolina averaging 6.8 yards per attempt on the ground. Despite this, Arizona’s defense limited the Panthers to 149 passing yards on 17 completions.

The Cardinals’ defense recorded three sacks in the game and held Carolina to a 42.9% third-down conversion rate. However, they did allow two passing touchdowns and struggled to stop the run.

In their 19-9 win over the Jets, the Rams’ defense allowed 321 total yards. They held the Jets to 75 rushing yards on just 20 attempts, giving up only 3.8 yards per attempt. The Rams allowed one passing touchdown and 246 passing yards, with the Jets completing 66.7% of their passes. Los Angeles also held the Jets to a 38.5% conversion rate on third down and recorded one sack.

  • Free MoneyLine Prediction UNDER 48 (Bet Now)

Cardinals vs. Rams Prediction: Spread

Following their week 16 loss to the Panthers, the Cardinals are now 7-8 and rank 17th in our NFL power rankings. They have a +0.1 scoring margin and are 9-6 against the spread this season. As underdogs, they are 6-2 ATS but just 2-4 as favorites.

Arizona’s O/U record stands at 7-7-1, with the over hitting in their last three games. Their contests have averaged 45.7 points, while the O/U line has averaged 46.8.

  • Through their last three regular season contests, Arizona has a record of 1-2. In these matchups, they ended with an ATS record of 1-2 and an over-under mark of 3-0.
  • Across their five previous road games, Arizona has an ATS mark of 2-3. Their straight up record in these matchups was 1-4 while averaging 19 points per game.

With four straight wins, the Rams have improved to 9-6 and now hold the top spot in the NFC West. After a week 12 loss to the Eagles, Los Angeles has bounced back with victories over the Saints, Bills, 49ers, and Jets. In week 16, they defeated New York 19-9, covering the 3-point spread. The O/U line was 47, and the teams combined for 28 points.

Heading into week 17, the Rams have an 81.2% chance of making the playoffs and winning their division. They rank 12th in our power rankings and have a scoring margin of -1.2 points per game. Against the spread, they are 8-7 this season and have covered in four straight games.

  • Over their last three regular season games, the Rams have gone 1-2 straight up. Across these games, their ATS record was just 1-2, while posting an over-under record of 2-1.
  • Los Angeles has played well in their previous five home games, going 5-0 straight up. In this stretch, they averaged 21 points per game while allowing 14. The team also performed well vs the spread at 5-0.
  • Free Spread Prediction Cardinals +6 (Bet Now)

Cardinals vs. Rams Pick: Cardinals +6

For this week 17 matchup between the Rams and Cardinals, we have the Cardinals as 6-point road underdogs. Our point spread pick is to take the Cardinals to cover as road underdogs, with the Rams coming out on top by a score of 22-20.

As for the over/under, with the line sitting at 48 points, we are leaning towards taking the under, with a projected combined score of 42 points.

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