Lutz’s Locks For Week 4 Of The NFL

Cardinals vs 49ers Prediction & NFL Odds For Week 5

ByUSA Wager

The 49ers are heavily favored in their week five matchup against the Cardinals, with the money line sitting at -358 for the 49ers and +280 for the Cardinals. The game, set for 4:05 ET on Sunday, October 6th at Levi’s Stadium in Santa Clara, CA, will be aired on FOX. The 49ers are -7.5 point favorites, and the over/under line is 49.5 points.

Prediction at a Glance for 49ers vs Cardinals

  • We have the 49ers winning this one by a score of 32 to 23
  • Not only do we have the 49ers winning straight-up, we have them covering the spread at -7.5
  • Look for this game to go over the line of 49.5 points

Betting Odds & Lines for this Game

  • Spread: Cardinals +7.5 | 49ers -7.5
  • Total: 49.5
  • MoneyLine: Cardinals +280 | 49ers -358

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Cardinals vs. 49ers Prediction: MoneyLine

James Conner was the leading rusher for the Cardinals in their 42-14 loss to the Washington Commanders, gaining 104 yards on 18 carries, including a touchdown and a long run of 20 yards. Arizona’s rushing attack averaged 5.7 yards per attempt and picked up 181 yards on the ground. Kyler Murray completed 16 of 22 passes for 142 yards, with one touchdown and being sacked four times.

Marvin Harrison Jr. led the team with 45 receiving yards, including a 19-yard touchdown reception. The Cardinals’ offense managed just 17 first downs and 115 total passing yards. Murray finished the game with a passer rating of 104.

The 49ers’ offense finished with 283 yards through the air in their 30-13 win over the Patriots. They also had 148 yards on the ground on 32 attempts. San Francisco recorded 19 first downs and converted on 53.8% of their third down attempts.

Quarterback Brock Purdy threw for 288 yards, completing 15 of 27 passes (55%) and throwing one touchdown. Jordan Mason led the team in rushing with 123 yards, averaging 5.1 yards per attempt, and finding the endzone once. Jauan Jennings was the top receiver, finishing with 88 yards.

  • Free MoneyLine Prediction 49ers -358 (Bet Now)

Cardinals vs. 49ers Prediction: Total

The Cardinals’ run defense had a tough game, giving up 216 yards on the ground to Washington in their 42-14 loss. Despite this, they only allowed 233 passing yards and 1 touchdown through the air. On the ground, Washington averaged 5.8 yards per attempt, and Arizona struggled to get off the field, allowing a 75% third-down conversion rate.

Arizona’s defense didn’t record any sacks in this game and had a tough time in the trenches, losing the tackles for loss battle. They did manage to come up with one interception, but opposing quarterbacks completed 86.7% of their passes against them.

The 49ers’ defense was dominant in their 30-13 win over the Patriots, allowing just 216 total yards and sacking Cam Newton six times. They defended the run well, giving up only 73 rushing yards on 24 attempts and limited the Patriots to a 31.2% conversion rate on third down.

Although they allowed one passing touchdown, the 49ers’ secondary held the Patriots to 143 yards through the air. San Francisco also came away with one interception and held New England to a 59.4% completion rate.

  • Free Total Prediction OVER 49.5 (Bet Now)

Cardinals vs. 49ers Prediction: Spread

The Cardinals are now 1-3 after a disappointing 42-14 loss to the Commanders. Arizona was favored by -3.5 at home but lost by 28 points. The combined 56 points exceeded the over/under line of 48.5 points.

Arizona initially kept things level at 7-7 after the 1st quarter, but Washington took control in the 2nd quarter, outscoring the Cardinals 10-0. The Commanders extended their lead in the 3rd quarter, and even though the Cardinals found the endzone twice, they still trailed 27-14 heading into the 4th. However, Washington dominated the 4th quarter, outscoring Arizona 15-0.

  • Through their last three regular season contests, Arizona has a record of 1-2. This includes going 1-2 vs. the spread along with an over-under mark of 2-1.
  • When looking at their past five road matchups, Arizona has an ATS record of 4-1 while averaging 23 per game. The team went 2-3 overall in these games.

The 49ers picked up a 30-13 win over the Patriots, improving their record to 2-2. Heading into the game, the 49ers were 10.5-point favorites, and their 17-point victory allowed them to easily cover the spread. The combined 43 points went over the O/U line of 42 points. San Francisco took an early 6-0 lead and didn’t look back, leading 20-3 at halftime.

In the 3rd quarter, the Patriots found the endzone to make it 20-10, but the 49ers quickly responded with a touchdown of their own. Although the Patriots and 49ers each added a touchdown in the 4th quarter, the 49ers came out on top. This game featured multiple turnovers and big plays, including a 63-yard field goal from Joey Slye right before halftime.

  • Spanning across their last three games, San Francisco have gone 3-0. In these games, they have a 2-1 record vs the spread and an over-under mark of 3-0.
  • Across the 49ers last five home games, the team averaged 27 points per game while allowing 22. Their record vs the spread in these contests was 2-3, while going 2-3 straight-up.
  • Free Spread Prediction 49ers -7.5 (Bet Now)

Cardinals vs. 49ers Pick: 49ers -7.5

Our pick vs. the spread is to take the 49ers to cover as home favorites in this week five matchup between the 49ers and Cardinals. The point spread lines have the 49ers at -7.5, and we have them winning 31-22.

For this week’s point spread pick, we are taking the 49ers to cover at home. And with the point spread lines at +7.5 in favor of the 49ers, we have them covering and winning 31-22. As for the over/under, with the line sitting at 49.5 points, we have a projected combined score of 53 points, making the over a good bet.

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