Bills vs Colts Prediction & NFL Odds For Week 10
The Colts, who are the underdog at +171 on the money line, will host the Buffalo Bills at 1:00 ET on Sunday, November 10th at Lucas Oil Stadium. The Bills are favored by -4 on the road, and this week 10 AFC matchup can be viewed on CBS. The Bills’ money line odds are -205, and the over/under line is set at 46 points.
Prediction at a Glance for Colts vs Bills
- We have the Colts winning this one by a score of 21 to 19
- Not only do we have the Colts winning straight-up, we have them covering the spread at +4
- We see this game finishing below the line of 46 points
Betting Odds & Lines for this Game
- Spread: Bills -4 | Colts +4
- Total: 46
- MoneyLine: Bills -205 | Colts +171
All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)
Bills vs. Colts Prediction: MoneyLine
Josh Allen has been solid for the Bills over his last three games, posting passer ratings of 95 in week 9, 102 in week 8, and 116 in week 7. Against the Dolphins in week 9, he threw for 235 yards and 3 touchdowns, with 1 interception. Buffalo’s offense has done a good job protecting Allen, allowing just one sack in each of the last three games.
Buffalo ranks 4th in our offensive power rankings, averaging 28.9 points per game. They are 15th in the NFL in passing yards per game (216.1) and 17th in rushing yards per game (119.1). The Bills have struggled in the red zone, converting just 5.1% of their opportunities, which ranks 28th in the league.
Heading into week 10, the Colts rank 23rd in our offensive power rankings, averaging 20.9 points per game, which puts them 21st in the NFL. They are 22nd in passing yards per game (193.7) and 16th in rushing, with 121.3 yards per game. On 3rd down, they convert 36.6% of the time, ranking 19th, and they are 12th in red zone conversion percentage.
Joe Flacco took over at QB in week 9, throwing for 179 yards on 16/27 passing, with 1 interception. Jonathan Taylor rushed for 48 yards on 13 carries, and Josh Downs led the team with 6 catches for 60 yards in their loss to the Vikings.
- Free MoneyLine Prediction Colts +171 (Bet Now)
Bills vs. Colts Prediction: Total
In their 30-27 win over the Dolphins, the Bills’ defense allowed 373 total yards. Miami found some success on the ground, rushing for 149 yards on 31 attempts. Buffalo defended the pass, allowing just 25 completions for 224 yards, with two passing touchdowns and an 89.3% completion percentage against them.
Buffalo struggled on third downs, allowing Miami to convert 50% of their third down attempts. The Bills’ defense managed just one sack in the game.
In their 21-13 loss to the Vikings, the Colts’ defense gave up 415 yards and allowed 82.9% of passes to be completed. They struggled to defend the pass, allowing 282 yards through the air, including three touchdowns. Despite this, the Colts did manage to come away with two interceptions.
On the positive side, the Colts’ defense recorded four sacks and won the tackles for loss battle with a differential of +4. However, the Colts allowed the Vikings to convert on 50% of their third downs.
- Free MoneyLine Prediction UNDER 46 (Bet Now)
Bills vs. Colts Prediction: Spread
Buffalo heads into week 10 on a four-game winning streak, including a 30-27 victory over the Dolphins in week 9. The win put the Bills at 7-2, keeping them atop the AFC East and 2nd in the conference standings. Our power rankings have Buffalo 4th, and they have a 98.5% chance of winning the division and a 99.6% chance of making the playoffs.
Buffalo has a +9.7 scoring margin this season and is 5-4 against the spread. They are 4-2 ATS as favorites and 1-2 as underdogs. Their O/U record is 5-4, with their games averaging 48.1 points compared to an average line of 45.8.
- Through their last three games, the Bills have a record of 3-0. The team has also been excellent vs the spread, going 2-1. Their over-under record in these games was 2-1.
- The Bills are 3-2 ATS in their last road games and 3-2 straight-up.
After a week 7 win over the Dolphins, the Colts have dropped two straight, including a 21-13 loss to the Vikings in week 9. This put Indy at 4-5, leaving them 2nd in the AFC South. They have a 37.2% chance of making the playoffs and a 9.7% chance of winning the division.
Against the spread, the Colts are 7-2, with a +0.6 scoring margin. They are 5-1 as underdogs and 2-1 as favorites. Their O/U record is 3-6, with the under hitting in four straight games.
- Through their last three games, the Colts have a record of 3-0. Their strong play has also resulted in an ATS mark of 3-0 (last 3). They had an over/under mark of 1-2 in those same games.
- Indianapolis has a 1-4 record in their last five home games. In this stretch, they averaged 19 points per game while allowing 22. The team also performed well vs the spread at 3-2.
- Free Spread Prediction Colts +4 (Bet Now)
Bills vs. Colts Pick: Colts Moneyline (+171)
Our pick vs. the spread is to take the Colts to cover as home favorites. Currently, the point spread lines have the Colts at -4, and we have them winning by a score of 24-22 in this week 10 matchup against the Bills.
For the over/under, with the line sitting at 46 points, we are leaning towards the under, as our projections have these teams finishing with 46 combined points.