49ers vs Buccaneers Prediction & NFL Odds For Week 10

On the money line, the 49ers are -245 favorites as they head into their week 10 matchup against the Buccaneers at 1:00 ET. The game, which is being played at Raymond James Stadium in Tampa, is also favoring the 49ers on the point spread, with FOX covering the NFC matchup. The Buccaneers are +204 on the money line and +5.5 on the point spread, with the over/under line set at 51 points.

Prediction at a Glance for Buccaneers vs 49ers

• We have the 49ers winning this one by a score of 31 to 24
• Not only do we have the 49ers winning straight-up, we have them covering the spread at -5.5
• Look for this game to go over the line of 51 points

Betting Odds & Lines for this Game

• Spread: 49ers -5.5 | Buccaneers +5.5
• Total: 51
• MoneyLine: 49ers -245 | Buccaneers +204

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

49ers vs. Buccaneers Prediction: MoneyLine

San Francisco enters week 10 ranked 10th in our offensive power rankings. They are 6th in the NFL in points per game, averaging 26.2, and 2nd in yards per game with 412.4. Despite ranking 19th in passing attempts, they are 4th in passing yards per game, with 253.4. On the ground, they average 159 rushing yards per game, which also ranks 4th in the league.

After a rough outing in week 7, Brock Purdy bounced back in week 8, throwing for 260 yards and a touchdown on 18/26 passing, with a passer rating of 114. George Kittle led the team with 6 catches for 128 yards, and Isaac Guerendo added 85 rushing yards on 14 carries. San Francisco scored 21 points in the 3rd quarter and converted 8 of 16 3rd downs in their win over the Cowboys.

Heading into week 10, the Buccaneers rank 7th in our offensive power rankings, and they are 5th in the NFL in both points per game (28.8) and yards per game (377.8). They average 250.8 passing yards per game, ranking 5th, on 35 attempts per game. On the ground, they rank 22nd in rushing attempts but still manage to rank 10th in rushing yards per game with 127. Tampa Bay has been strong on 3rd down, converting 51.8% of their attempts, which ranks 2nd in the NFL.

Baker Mayfield posted a passer rating of 112 in week 9, throwing for 200 yards and 2 touchdowns without an interception. Cade Otton led the team with 8 catches for 77 yards and a touchdown. Bucky Irving had 24 rushing yards on 7 carries. Tampa Bay scored 10 points in the 3rd quarter and converted all 3 of their red zone opportunities against the Chiefs.

• Free MoneyLine Prediction 49ers -245 (Bet Now)

49ers vs. Buccaneers Prediction: Total

In their 30-24 win over the Cowboys, the 49ers’ defense allowed just 56 rushing yards on 19 attempts, giving up only 2.9 yards per attempt on the ground. Despite allowing 236 passing yards, San Francisco defended well on third downs, allowing just a 33.3% conversion rate. They also came away with two interceptions, helping to limit Dallas to 24 points.

The 49ers allowed 25 completions on 37 attempts (65.8%) and gave up two passing touchdowns. San Francisco’s defense recorded two sacks and had a +6 advantage in quarterback hits.

In their 30-24 overtime loss to the Chiefs, the Buccaneers’ defense allowed three passing touchdowns and gave up 260 yards through the air. The Chiefs completed 77.3% of their passes and converted 66.7% of their third down attempts. Despite this, Tampa Bay’s defense managed to sack Patrick Mahomes four times and had more tackles for loss than the Chiefs.

The Buccaneers’ defense held the Chiefs to 124 yards on 35 rushing attempts, averaging 3.5 yards per attempt. Tampa Bay will be looking to improve on defending the pass more effectively in their next game, as they allowed big plays through the air in their most recent outing.

• Free Total Prediction OVER 51 (Bet Now)

49ers vs. Buccaneers Prediction: Spread

Heading into week 10, the 49ers sit at 4-4 after a 30-24 win over the Cowboys in week 8. San Francisco was favored by 5.5 points and covered the spread, bringing their ATS record to 4-4. They have been favored in all of their games so far this season. The O/U line for their game vs Dallas was 47.5 points, and the teams combined for 54. The 49ers’ O/U record is 5-3, with their games averaging 49 points per game.

Despite their .500 record, the 49ers rank 6th in our NFL power rankings and have a 40.4% chance of making the playoffs and a 33.0% chance of winning the NFC West. They are currently 3rd in the division with a 1-2 record. San Francisco is 3-2 at home and 1-2 on the road this season.

• San Francisco will look to keep things rolling as they have put together a mark of 2-1 over their past three games. In addition, their ATS record over this stretch is 2-1 while posting a 2-1 over-under mark.
• Across the 49ers last five road games, the team averaged 25 points per game while allowing 21. Their record vs the spread in these contests was 2-3, while going 2-3 straight-up.

Heading into week 10, the Buccaneers are looking to snap a three-game losing streak, which includes a 30-24 road loss to the Chiefs in week 9. Despite the defeat, Tampa Bay covered the spread as 8.5-point underdogs. The O/U line was 45.5, and the teams combined for 54 points, marking the sixth straight game in which the Bucs have hit the over.

With a 4-5 record, the Bucs have a +1.8 scoring margin and are 5-4 against the spread. They rank 11th in our power rankings and have a 40.8% chance of making the playoffs. Their O/U record is 7-2 this season.

• Over their last three regular season games, the Buccaneers have gone 1-2 straight up. The team’s record vs the spread was just 1-2, in addition to an over-under mark of 3-0.
• Tampa Bay has a 2-3 record in their last five home games. In this stretch, they averaged 29 points per game while allowing 28. The team also performed well vs the spread at 3-2.

• Free Spread Prediction 49ers -5.5 (Bet Now)

49ers vs. Buccaneers Pick: 49ers -5.5

Our model has the 49ers coming out on top by a score of 31-25 in their week 10 matchup against the Buccaneers. With the 49ers being 5.5-point favorites on the road, we are leaning towards taking them to cover the spread.

For this week’s over/under pick, we like taking the over, with a projected combined score of 56 points and the line sitting at 51 points.