49ers vs Bills Prediction & NFL Odds For Week 13
The 49ers and Bills are set to kick off at 8:20 ET on Sunday, December 1st at Highmark Stadium in Orchard Park, NY. The game will be broadcast on NBC. The Bills are the heavy favorite with a point spread of -7 and money line odds of -319. This week 13 non-conference matchup sees the 49ers as +252 underdogs. The over/under line is set at 45.5 points.
Prediction at a Glance for Bills vs 49ers
- We have the 49ers winning this one by a score of 25 to 17
- Not only do we have the 49ers winning straight-up, we have them covering the spread at +7
- We see this game finishing below the line of 45.5 points
Betting Odds & Lines for this Game
- Spread: 49ers +7 | Bills -7
- Total: 45.5
- MoneyLine: 49ers +252 | Bills -319
All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)
49ers vs. Bills Prediction: MoneyLine
Heading into week 13, the 49ers are 13th in the NFL in scoring, averaging 23.6 points per game. They rank 4th in passing yards per game (246.2) despite being 20th in passing attempts, and they are 7th in rushing yards per game, with 138.4. San Francisco ranks 6th in the league in 3rd-down conversions but is 21st in red zone conversion percentage, despite being 6th in red zone attempts.
Brandon Allen started in week 12, throwing for 197 yards, with 1 touchdown and 1 interception. Christian McCaffrey had 31 yards on 11 carries, and George Kittle led the team with 6 catches for 82 yards. Before Allen’s start, Brock Purdy threw for 159 yards in week 11 and 353 yards in week 10.
In our offensive power rankings, the Bills are currently 3rd in the NFL, and they are 3rd in points per game, averaging 29.1. They are 13th in passing yards per game (226.1) and 19th in passing attempts. On the ground, they rank 11th in rushing yards per game (119.2) on 27.9 attempts per game. Buffalo is 9th in the league in 3rd-down conversions, with a 42% success rate, and they rank 2nd in red zone attempts, although they are 28th in conversion percentage, scoring on just 6.4% of their trips.
Josh Allen threw for 262 yards (27/40) with one touchdown and one interception in week 11 against the Chiefs. He also led the team in rushing, with 55 yards on 12 carries. Khalil Shakir was the top receiver, with 8 catches for 70 yards. Buffalo scored 14 points in the 4th quarter and converted 9 of 15 3rd-down attempts, while going 3/4 in the red zone.
- Free MoneyLine Prediction 49ers +252 (Bet Now)
49ers vs. Bills Prediction: Total
In their 38-10 loss to the Packers, the 49ers’ defense allowed 325 yards and 156 passing yards. Despite this, they gave up two passing touchdowns and allowed the Packers to complete 46.2% of their third down attempts. San Francisco struggled to stop the run, allowing 169 yards on 42 attempts, with the 49ers’ two sacks and two tackles for loss.
The 49ers’ defense held the Packers to a 6.8 yards per attempt in the passing game, but they still gave up big plays and two touchdowns.
The Bills’ defense gave up 181 passing yards in their 30-21 win over the Chiefs, but did allow three passing touchdowns. They defended the run well, allowing just 78 yards on 17 attempts. Buffalo’s defense also came up with two interceptions and held Kansas City to a 23% conversion rate on third down.
Buffalo allowed the Chiefs to complete 69.7% of their passes and gave up 259 total yards. Despite allowing three passing touchdowns, the Bills’ defense played a key role in the victory by forcing turnovers and limiting Kansas City’s ground game.
- Free MoneyLine Prediction UNDER 45.5 (Bet Now)
49ers vs. Bills Prediction: Spread
Heading into week 13, the 49ers are looking to snap a two-game losing streak, which includes a 38-10 loss to the Packers in week 12. San Francisco was a 6.5-point underdog in that matchup but couldn’t keep it close, dropping their record to 5-6. The 49ers are now 4th in the NFC West with a 1-3 division record and rank 11th in the NFC.
Despite their sub-.500 record, the 49ers are 7th in our NFL power rankings, and they have a 16.4% chance of making the playoffs. Against the spread, they are 4-7 and have failed to cover in three straight games. Their O/U record stands at 6-5, with their games averaging 47.3 points compared to an O/U line of 46.6.
- San Francisco has put together a record of 1-2 in their last three games (regular season). This includes going 0-3 vs. the spread along with an over-under mark of 1-2.
- In their last five games away from home, the 49ers have a straight up record of 2-3 while going 1-4 vs the spread. The team’s offense averaged 22 points per game in these contests.
With a 9-2 record, the Bills sit atop the AFC East and have a 100% chance of winning the division and making the playoffs, according to our projections. Buffalo is on a six-game winning streak, including a 30-21 victory over the Chiefs in week 11. They also have a +9.6 scoring margin and rank third in our NFL power rankings.
The over has hit in the Bills’ last three games, bringing their O/U record to 7-4 this season. Their games have averaged 48.5 points, with an average line of 46. Buffalo is 7-4 against the spread and has covered in two straight games.
- Over their last three games, the Bills have gone 3-0 straight up. In addition, their ATS record over this stretch is 2-1 while posting a 3-0 over-under mark.
- Across their last five home contests, Buffalo has been good against the spread posting a mark of 3-2. Their overall mark in these games was 3-2, while averaging 22 points per game.
- Free Spread Prediction 49ers +7 (Bet Now)
49ers vs. Bills Pick: 49ers Moneyline (+252)
Our pick vs. the spread for this 49ers vs. Bills matchup is to take the 49ers to cover as road underdogs. Right now, the point spread lines have the 49ers at +7, and with our projected final score being 20-18 in favor of the 49ers, there is a lot of value in taking them to cover.
For an over/under pick, we are leaning towards taking the under, with a projected combined score of 38 points, well below the O/U line of 45.5.
