Reds vs Guardians Prediction & MLB Odds For Wednesday, September 25th

Cleveland comes into this interleague matchup as the heavy favorite, with their money line odds sitting at -148. As for the Reds, they have a money line payout of +124, and the over/under line is currently at 8 runs. First pitch from Progressive Field is set for 6:40 PM ET, and BSGL will be televising this one.

The Guardians will be starting Joey Cantillo, while the Reds are sending Jakob Junis to the mound. Cincinnati is 76-82 this season and has lost two straight, and they are the 4th place team in the NL Central. Cleveland is 91-67 and leads the AL Central.

Betting Odds & Lines for this Game

• Spread: Reds 1.5 (-171) | Guardians -1.5 (+141)
• Total: 8
• MoneyLine: Reds +124 | Guardians -148

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Reds vs. Guardians Prediction: Moneyline

Cleveland cruised to an easy 6-1 win over the Reds in the most recent game of this series. The Guardians had a huge 1st inning, scoring three of their six runs. As for the Reds, they scored their only run in the 4th. Heading into the game, the Guardians were favored at -202 on the money line.

Tanner Bibee pitched well for the Guardians in this one, going seven innings and giving up just one run. He finished the game with seven strikeouts but issued two walks. On the other side, Carson Spiers got the start for the Reds, going just four innings and giving up three earned runs.

Cleveland’s two homers came from Lane Thomas and Kyle Manzardo. Thomas, Josh Naylor, Jose Ramirez, and Will Brennan each had two RBIs for the Guardians’ offense.

Cincinnati is 76-82 overall heading into today’s road matchup vs. the Guardians. The Reds trail the Brewers by 14.5 games in the NL Central and are 4th in the division. They come into today’s game having dropped two straight games, and they lost the series opener vs. the Guardians.

At home, the Reds are 39-42 this year compared to 37-40 on the road. As the underdog, the Reds are 25-34 this year, and they are just under .500 at 35-34 as the favorite. Cincinnati’s overall series record is 20-28-3, and they are 5-5 over their last 10 games.

Cleveland is 91-67 overall and leads the AL Central by 7.5 games over the Royals. The Guardians are currently on a three-game winning streak at home, and they are 49-28 at home this season. So far, they have gone 42-39 on the road. The Guardians have been good as the favorite this year, going 63-34 but are just 28-33 as the underdog.

So far, the Guardians have gone 30-22 against other teams in the AL Central. They will take on the Reds at home today, and they lead the series 1-0. Cleveland has an overall series record of 28-16-6 this year. Looking at their recent form, the Guardians are 7-3 over their last 10 games.

Reds vs. Guardians Prediction: Over/Under

The Cincinnati Reds are on the road against the Cleveland Guardians today, with the over/under line set at 8 runs. The Reds have an average combined run average of 8.7 runs per game this season, and their over/under record is 73-78. When the over/under line is set at 8 runs, their record is 7-13. Overall, 70.9% of their games this season have had over/under lines set higher than 8 runs.

Elly De La Cruz has been swinging a hot bat of late, going 10/34 in his last eight games with one homer and five RBIs. For the season, he is batting .260 with a team-high 25 homers and 74 RBIs. Spencer Steer and Jeimer Candelario are also tied for 2nd on the team with 20 homers, but Steer is batting just .229, and Candelario is hitting just .225.

As a team, the Reds are averaging 4.4 runs per game, which is 15th in the league. Their team batting average of .232 is 19th in the MLB. They are also 14th in home runs and have the league’s 10th best isolated power figure. The Reds will look to get their offense going after scoring just 3 runs in their most recent game.

When the Cleveland Guardians host the Cincinnati Reds, the over/under line is set at 8 runs. The Guardians have played to an over/under record of 68-79 on the season, with an average combined run average of 8.3 runs per game. When the over/under line is set at 8 runs, Cleveland has gone 13-20-6, and the over/under line has been set at 8 runs in 44.3% of their games this season. Currently, the Guardians are on a 2-game under streak.

For the season, the Guardians are averaging 4.4 runs per game, which is 14th in the league. At home, they have been even better, averaging 4.7 runs per contest. As a team, they are batting just .238, but their team on-base percentage of .308 is 14th in the league. The Guardians are also one of the league’s best teams at avoiding strikeouts, as they are 4th in the league in this category.

José Ramírez has been one of the league’s top power hitters this season, as his 37 home runs are 7th in the league. He is also 3rd in the MLB with 112 RBIs. Over his last five games, he has gone 7/20 with two homers and five RBIs. Kyle Manzardo and Lane Thomas have also homered in two of their last five games, with Manzardo hitting .333 and Thomas batting .250 during this stretch.

Reds vs. Guardians Prediction: Spread

When betting on the Reds’ run line, it’s best to take them as the underdog. Cincinnati is 56-33 against the run line as the underdog, compared to 29-40 as the favorite. The Reds have been a solid bet on the run line on the road, going 47-30, but they have failed to cover in their last two road games. Their average run differential in winning games is +3.8, while it’s -3.4 in their losses.

Jakob Junis gets the start for the Reds today as he faces off against the Guardians on the road. So far, he has made 23 appearances and five starts. Junis’ record for the season is 4-0, and his ERA is an impressive 2.61. Looking at his numbers, Junis has a WHIP of .84 and has issued just 1.02 walks per nine innings. One area of concern could be home runs, as he has given up seven homers. In his last outing, Junis went six innings, giving up one earned run and coming away with a no-decision. He has finished with a no-decision in each of his last three outings.

As a run line bet, the Cleveland Guardians have been a .500 team this season, going 81-77. They’ve been slightly better at home, going 38-39. Their average run differential is +0.6 runs per game, and they’ve been a better bet on the road, going 43-38 against the run line.

Left-hander Joey Cantillo gets the start for the Guardians today as he faces the Reds at home. So far this season, he has made seven starts and one of them was a quality start. Cantillo’s ERA for the season is 4.63, along with a record of 2-3. In his 35 innings of work, he has a WHIP of 1.20 and is averaging 9.51 strikeouts per nine innings. Cantillo’s most recent outing came on September 19th, where he went 4 1/3 innings, giving up one earned run on six hits. He finished with a no-decision in that outing.

Reds vs. Guardians Pick: Guardians ML -148

Our prediction for this one is that the Guardians will pick up a 5-4 win at home, and with their money line sitting at -148, this is the way we recommend playing this one.

Looking at the starting pitchers, we have Joey Cantillo finishing with seven strikeouts, which is good for fourth among starters today. As for Jakob Junis, we have him finishing with six K’s, which is eighth best.