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Jaguars vs Colts Prediction & NFL Odds For Week 18

FOX will broadcast the week 18 AFC South matchup between the Jaguars and Colts from Lucas Oil Stadium in Indianapolis at 1:00 ET. The Colts are favored at -223 on the money line and -5 on the point spread. The over/under line is set at 45 points. The Jaguars’ record is missing, and the Colts need to add their record as well.

Prediction at a Glance for Colts vs Jaguars

  • We have the Jaguars winning this one by a score of 28 to 20
  • Not only do we have the Jaguars winning straight-up, we have them covering the spread at +5
  • Look for this game to go over the line of 45 points

Betting Odds & Lines for this Game

  • Spread: Jaguars +5 | Colts -5
  • Total: 45
  • MoneyLine: Jaguars +186 | Colts -223

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Jaguars vs. Colts Prediction: MoneyLine

Heading into week 18, the Jaguars rank 23rd in our offensive power rankings. They are 24th in the NFL in scoring, averaging 18.6 points per game, and 26th in total yards with 305.4 per game. Jacksonville is 23rd in passing yards (204.4) and 26th in rushing yards (101) per game. They sit 18th in the league in 3rd-down conversion rate at 37.4% and are 15th in red zone conversion percentage.

Mac Jones had a strong week 17 performance, posting a passer rating of 122 with 174 yards and 2 touchdowns on 15/22 passing. Brian Thomas Jr. led the team in receiving with 7 catches for 91 yards and a touchdown, while Travis Etienne Jr. had 49 rushing yards on 15 carries. Jacksonville converted 8 of 13 3rd-down attempts and scored on both of their red zone trips.

Heading into week 18, the Colts rank 25th in our offensive power rankings. They are 16th in the NFL in points per game (21.9) and 15th in total yards per game (328.9). Indianapolis has leaned heavily on the run game, ranking 7th in rushing attempts and 8th in rushing yards per game (134.6). Meanwhile, they rank 27th in passing attempts and 26th in passing yards per game. On 3rd down, the Colts are 15th in the league, converting 38.2% of their attempts.

Jonathan Taylor has been a workhorse for the Colts, carrying the ball 32 times for 125 yards and 2 touchdowns in week 17. Before that, he rushed for 218 yards on 29 carries in week 16 and had 107 yards in week 15. Joe Flacco threw for 330 yards (26/38) and 2 touchdowns in week 17, with Alec Pierce leading the team in receiving with 6 catches for 122 yards.

  • Free MoneyLine Prediction Jaguars +186 (Bet Now)

Jaguars vs. Colts Prediction: Total

In their 20-13 win over the Titans, the Jaguars’ defense allowed 178 passing yards and 159 yards on the ground. The Jaguars gave up 337 total yards, with Tennessee converting on 50% of their third down attempts. Despite this, Jacksonville’s defense came up with three sacks and an interception.

The Jaguars defended 19 completions and held the Titans to 61.3% completions. They also forced three quarterback hits and four tackles for loss.

In the Colts’ 45-33 loss to the Giants, their defense struggled to generate pressure, finishing with no sacks and just three quarterback hits. The Giants’ passing game thrived, racking up 309 yards through the air and completing 73.9% of their passes. Indianapolis gave up four passing touchdowns and allowed big plays, as the Giants averaged 13.4 yards per passing attempt.

On third downs, the Colts allowed the Giants to convert 53.8% of their chances. Despite their defensive struggles, the Colts did limit the Giants to 80 rushing yards on 30 attempts.

  • Free Total Prediction OVER 45 (Bet Now)

Jaguars vs. Colts Prediction: Spread

Jacksonville snapped a four-game losing streak in week 17, defeating the Titans 20-13 to improve to 4-12. The Jaguars were slight favorites at -0.5 and covered the spread, but the teams fell short of the 38.5-point O/U line. Jacksonville is now 8-8 on O/Us this season, with the under hitting in their last two games.

Heading into week 18, the Jaguars rank 26th in our power rankings and have been eliminated from playoff contention. They are 8-7-1 against the spread, with a 6-4-1 record as underdogs and a 2-3 mark as favorites.

  • Jacksonville has put together a record of 1-2 in their last three games (regular season). Against the spread, Jacksonville went 1-2 in these games and finished with an over-under mark of 1-2.
  • Across the Jaguars last five road games, the team averaged 13 points per game while allowing 28. Their record vs the spread in these contests was 2-3, while going 1-4 straight-up.

Heading into week 18, the Colts sit 25th in our power rankings and have been eliminated from playoff contention. After a week 16 win over the Titans, they couldn’t keep the momentum going, losing 45-33 to the Giants in week 17. The Colts were 7.5-point favorites but couldn’t get the win, dropping their record to 7-9.

Indianapolis is 9-7 against the spread this season, with a scoring margin of -3.3 points per game. They are 6-4 ATS as underdogs and 3-3 as favorites. Their O/U record is 9-7, with the over hitting in four straight games.

  • Indianapolis has put together a record of 1-2 in their last three games (regular season). In these matchups, they ended with an ATS record of 1-2 and an over-under mark of 2-1.
  • Across the Colts last five home games, the team averaged 22 points per game while allowing 29. Their record vs the spread in these contests was 1-4, while going 2-3 straight-up.
  • Free Spread Prediction Jaguars +5 (Bet Now)

Jaguars vs. Colts Pick: Jaguars Moneyline (+186)

Our pick vs. the spread is to take Jacksonville to cover as road underdogs in this week 18 matchup against the Colts. The Jaguars are currently +5 point spreads, and we have them winning 26-20.

As for the over/under, with the line sitting at 45 points, we are leaning towards taking the over, with our projections coming in at 46 combined points.

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