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Cardinals vs Panthers Prediction & NFL Odds For Week 16

ByUSA Wager

The Panthers, who are +171 on the money line, will host the Cardinals at 1:00 ET on Sunday, December 22nd at Bank of America Stadium in Charlotte, NC. The Cardinals are favored on the road with a money line of -207 and a -4 point spread. This week 16 NFC matchup is being televised on FOX, and the over/under line is set at 47 points.

Prediction at a Glance for Panthers vs Cardinals

  • We have the Cardinals winning this one by a score of 22 to 19
  • Even though we like the Cardinals to win, our ATS pick is to take the Panthers at +4
  • We see this game finishing below the line of 47 points

Betting Odds & Lines for this Game

  • Spread: Cardinals -4 | Panthers +4
  • Total: 47
  • MoneyLine: Cardinals -207 | Panthers +171

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Cardinals vs. Panthers Prediction: MoneyLine

Heading into week 16, the Cardinals are 12th in our offensive power rankings. They’re 13th in the NFL in scoring, averaging 22.4 points per game, and 11th in total yards with 351.4 per game. Arizona ranks 21st in passing yards, with 209.9 per game, on 30.6 attempts per game, which ranks 22nd. On the ground, they’re 6th in the NFL with 141.5 rushing yards per game on 27.5 attempts per contest. The Cardinals are 9th in the NFL in 3rd-down conversion rate (42.9%) and 16th in red zone conversion percentage.

Kyler Murray is coming off a strong week 15 performance, going 23/30 for 224 yards without a touchdown or interception. He finished with a passer rating of 97 after throwing 2 interceptions in each of his previous two games. James Conner rushed for 110 yards and 2 touchdowns on 16 carries, while Trey McBride led the team with 9 catches for 87 yards. Arizona scored 14 points in the 4th quarter against the Patriots, converting 10 of 15 3rd-down attempts and 3 of 4 red zone trips.

Heading into week 16, the Panthers rank 27th in our offensive power rankings. They are 25th in the NFL in points per game (17.6) and 30th in yards per game (288.9). Carolina ranks 29th in passing yards per game (186) on 32.7 attempts per game, while they sit 22nd in rushing yards per game (102.9) on 23.6 attempts per game. The Panthers are 26th in the league in 3rd-down conversions, with a 34.7% success rate, but they have been more efficient in the red zone, ranking 11th with a 33.3% conversion rate.

Bryce Young threw for 219 yards (19/28) with one touchdown and two interceptions in week 15 against the Cowboys. He was sacked six times. Chuba Hubbard led the team in rushing with 32 yards on 10 carries, while Jalen Coker had 4 catches for 110 yards and a touchdown. Carolina struggled on 3rd down, converting only 3 of 11 attempts, but they scored on 1 of 2 red zone trips.

  • Free MoneyLine Prediction Cardinals -207 (Bet Now)

Cardinals vs. Panthers Prediction: Total

In their 30-17 win over the Patriots, the Cardinals’ defense allowed just 116 rushing yards on 24 attempts. Despite giving up 195 passing yards, they held New England to 82.6% completions and allowed just one passing touchdown. Arizona defended well on third downs, allowing no conversions, and came away with one interception.

The Cardinals’ defense also recorded two sacks, and their players combined for four tackles for loss. New England finished with 311 total yards in the game.

In their 30-14 loss to the Cowboys, the Panthers’ defense allowed 410 total yards and struggled to defend the run, giving up 211 rushing yards on 40 attempts. Despite holding Dallas to 199 passing yards, Carolina allowed three passing touchdowns and a 62.1% completion percentage. The Panthers’ run defense was a significant issue, allowing the Cowboys to average 5.3 yards per attempt on the ground.

Carolina’s defense managed just one sack in the game and lost the battle in the tackles for loss and quarterback hit differentials, finishing with -6 and -7, respectively. Additionally, the Panthers allowed the Cowboys to convert on 50% of their third down attempts.

  • Free MoneyLine Prediction UNDER 47 (Bet Now)

Cardinals vs. Panthers Prediction: Spread

After three straight losses, the Cardinals got back to .500 with a 30-17 win over the Patriots in week 15. Arizona entered the game as 6-point favorites and covered the spread, bringing their ATS record to 9-5. They’ve been better as underdogs this year, going 6-2 in those games. The O/U line for this game was 46.5, and the teams combined for 47 points, giving the Cardinals two straight overs.

Arizona is now 7-7 on the season, putting them 3rd in the NFC West. They are 2-2 in division games and 3-6 in the conference. Our power rankings have the Cardinals 14th heading into week 16, and they have a 12.6% chance of making the playoffs. Their odds of winning the division are 12.2%.

  • The Cardinals have gone 1-2 over their last three regular season games. They have held up well vs the spread in these matchups, going 2-1 as well as an over-under record of 2-1.
  • When looking at their past five road matchups, Arizona has an ATS record of 3-2 while averaging 18 per game. The team went 2-3 overall in these games.

Carolina’s losing streak now sits at four games following their 30-14 home loss to the Cowboys in week 15. The Panthers were 2.5-point favorites, but the defeat dropped their record to 3-11, including 2-6 at home. They rank 32nd in our power rankings and have no chance of making the playoffs.

Carolina is 6-8 against the spread, with all six of their ATS wins coming as underdogs. Their average scoring margin is -12.2 points per game. The over has hit in 10 of their 14 games, with their matchups averaging 47.5 points per game.

  • Through their last three regular season contests, Carolina has a record of 0-3. Across this span, their ATS record sits at 2-1 to go along with an over-under mark of 3-0.
  • In their last five games at home, the Panthers have a straight up record of 1-4 while going 2-3 vs the spread. The team’s offense averaged 16 points per game in these contests.
  • Free Spread Prediction Panthers +4 (Bet Now)

Cardinals vs. Panthers Pick: Panthers +4

Our pick vs. the spread is to take the Panthers to cover as home underdogs. Right now, the point spread lines have the Panthers at +4, and our projected final score is 21-18 in favor of the Cardinals. This is a week 16 matchup between the Panthers and Cardinals.

For the over/under line, we have a lean towards the under, with a projected combined score of 39 points, which is well below the O/U line of 47 points.

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