Bills vs Lions Prediction & NFL Odds For Week 15

The Lions are favored at -1.5 as they host the Bills at 4:25 ET on Sunday, December 15th at Ford Field in Detroit. The Lions’ money line odds are -129, and the over/under line is set at 55 points. Buffalo’s record is not provided. This week 15 non-conference matchup is being televised on CBS.

Prediction at a Glance for Lions vs Bills

• We have the Bills winning this one by a score of 29 to 22
• Not only do we have the Bills winning straight-up, we have them covering the spread at +1.5
• We see this game finishing below the line of 55 points

Betting Odds & Lines for this Game

• Spread: Bills +1.5 | Lions -1.5
• Total: 55
• MoneyLine: Bills +107 | Lions -129

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Bills vs. Lions Prediction: MoneyLine

Heading into week 15, the Bills are 2nd in our offensive power rankings, averaging 30.5 points per game. They rank 10th in the NFL with 355 passing yards per game, 20th in passing attempts, and 12th in passing yards per game (229.3). On the ground, they are 9th in rushing attempts and 11th in rushing yards per game (125.7). Buffalo ranks 8th in 3rd-down conversions with a 43.4% success rate and is 28th in red zone conversion percentage.

Josh Allen threw for 342 yards and 3 touchdowns (22/37) in week 14, with no interceptions or sacks. He also led the team in rushing with 82 yards and 3 touchdowns. Khalil Shakir had 5 catches for 106 yards, while the Bills scored 21 points in the 4th quarter.

Jared Goff has been playing well for the Lions, posting a passer rating of 109 in week 14, with 283 yards, 3 touchdowns, and 1 interception against the Packers. He completed 32 of 41 passes in that game. Before that, he threw for 221 yards and 2 touchdowns in week 13 and had 269 yards in week 12. Jameson Williams led the team in receiving in week 14, with 5 catches for 80 yards, following his 64-yard performance in week 12. Amon-Ra St. Brown had 73 yards in week 13.

Detroit’s offense ranks 3rd in our power rankings, leading the NFL with 32.1 points per game. They are 2nd in total yards per game (394.8) and 4th in passing yards per game (243.8). Despite ranking 22nd in passing attempts, they are 4th in rushing yards per game, with 151.1, on 32.5 attempts per game. They also rank 4th in 3rd-down conversions, with a 45.8% success rate.

• Free MoneyLine Prediction Bills +107 (Bet Now)

Bills vs. Lions Prediction: Total

In their 44-42 loss to the Rams, the Bills’ defense struggled to get off the field, allowing the Rams to convert on 73.3% of their third down attempts. Buffalo’s defense gave up 320 yards through the air on 23 completions, and they allowed two passing touchdowns. The Rams also found success on the ground, rushing for 137 yards on 42 attempts.

Buffalo’s defense failed to record a sack in the game, despite winning the QB hit and tackles for loss differentials. The Rams’ passing attack was highly efficient, completing 76.7% of their passes and averaging 10.7 yards per attempt.

In their 34-31 win over the Packers, the Lions’ defense allowed just 199 passing yards on 12 completions. Green Bay managed only a 20% conversion rate on third down. Detroit defended the run well, allowing just 99 yards on 24 attempts. They also gave up one passing touchdown and recorded one sack.

The Lions’ defense pressured the quarterback, finishing with a +4 advantage in QB hits. Despite this, they did lose the tackles for loss battle by a margin of -2. Overall, the Lions’ defense was tough to move the ball against, as the Packers finished with only 298 total yards.

• Free MoneyLine Prediction UNDER 55 (Bet Now)

Bills vs. Lions Prediction: Spread

With a 10-3 record, the Bills hold the top spot in the AFC East and rank 2nd in our NFL power rankings. They have a +9.9 scoring margin and are 8-5 against the spread, including a 7-3 record as favorites. Buffalo has a 100% chance of making the playoffs and winning the division.

In week 14, the Bills couldn’t extend their win streak to five games, falling 44-42 to the Rams. They were 3.5-point favorites but couldn’t get the win, and the 86 combined points easily hit the over. Buffalo had no trouble covering the spread in week 13, beating the 49ers 35-10.

• Through their last three games, the Bills have a record of 2-1. In these games, they have a 2-1 record vs the spread and an over-under mark of 2-1.
• When looking at their past five road matchups, Buffalo has an ATS record of 3-2 while averaging 29 per game. The team went 3-2 overall in these games.

With their 34-31 win over the Packers in week 14, the Lions extended their winning streak to 11 games and improved to 12-1, giving them a firm hold on the top spot in our power rankings. Detroit has a +14.1 scoring margin this season and is 9-3-1 against the spread. They are 8-3-1 as favorites and 1-0 as underdogs. Their O/U record is 6-6-1, with their games averaging 50.1 points compared to a 49.9-point line.

Heading into week 15, the Lions have a 100% chance of making the playoffs and an 89% chance of winning the NFC North. They are 4-0 in division games and 8-1 in conference play. Detroit is 6-1 at home and 6-0 on the road.

• Detroit will look to keep things rolling as they have put together a mark of 3-0 over their past three games. Their record vs the spread in these matchups is less impressive at 1-1-1, while posting an over-under record of 2-1.
• The Lions are 4-1 ATS in their last home games and 5-0 straight-up.

• Free Spread Prediction Bills +1.5 (Bet Now)

Bills vs. Lions Pick: Bills Moneyline (+107)

For this week 15 matchup between the Bills and Lions, we have the Bills coming out on top by a score of 28-26. Despite the point spread being close, our pick vs. the spread is to take the Bills to cover as road underdogs. Currently, the point spread has the Bills at +1.5, making them our pick to cover.

As for the over/under, with the line sitting at 55 points, we have a slight lean towards the under, with a projected combined score of 54 points.