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49ers vs Packers Prediction & NFL Odds For Week 12

ByUSA Wager

The 49ers and Packers will face off at Lambeau Field in Green Bay on Sunday, November 24th at 4:25 ET. The Packers are favored at -138 on the money line, with the 49ers at +116. The 49ers are 2.5-point underdogs on the road, and the over/under line is set at 48 points. This week 12 matchup is being televised on FOX.

Prediction at a Glance for Packers vs 49ers

  • We have the 49ers winning this one by a score of 25 to 19
  • Not only do we have the 49ers winning straight-up, we have them covering the spread at +2.5
  • We see this game finishing below the line of 48 points

Betting Odds & Lines for this Game

  • Spread: 49ers +2.5 | Packers -2.5
  • Total: 48
  • MoneyLine: 49ers +116 | Packers -138

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

49ers vs. Packers Prediction: MoneyLine

Heading into week 12, the 49ers sit 10th in our offensive power rankings. They are 8th in the NFL in scoring, averaging 25 points per game, and rank 2nd in total yards with 398.9 per game. Despite ranking 19th in passing attempts, they are 4th in passing yards, with 251.1 per game. On the ground, they average 147.8 rushing yards per game, ranking 7th, on 29.7 attempts per game.

San Francisco has been strong on 3rd down, converting 45.4% of their attempts, which ranks 4th in the league. However, they have struggled in the red zone, ranking 20th in conversion percentage, despite being 4th in red zone attempts. Brock Purdy threw for 159 yards and a touchdown in week 11, with Jauan Jennings leading the team with 10 catches for 91 yards.

Heading into week 12, the Packers rank 12th in our offensive power rankings. They are 4th in the NFL in yards per game (387.6) and 8th in points per game (25). Despite ranking 21st in passing attempts, they are 8th in passing yards per game, with Jordan Love throwing for 261 yards (13/17) and a touchdown in week 11. Christian Watson led the team with 150 receiving yards on 4 catches.

On the ground, Green Bay ranks 6th in rushing attempts and 4th in rushing yards per game (149.9). Josh Jacobs had 76 yards and a touchdown on 18 carries in week 11. The Packers have struggled on 3rd down, ranking 20th in conversion percentage (36.6%) and converting just 1 of 5 attempts in their last game.

  • Free MoneyLine Prediction 49ers +116 (Bet Now)

49ers vs. Packers Prediction: Total

In their 20-17 loss to the Seahawks, the 49ers’ defense allowed 195 passing yards on 25 completions. Despite this, they did not give up any passing touchdowns. They also forced one interception and recorded four sacks. The 49ers’ run defense allowed 94 yards on 23 attempts, and overall, they held Seattle to 289 total yards. The Seahawks converted 46.2% of their third down attempts.

In their 20-19 win over the Bears, the Packers allowed 212 passing yards on 23 completions. The Bears ran for 179 yards on 34 attempts, with Green Bay struggling to stop the run, allowing 5.3 yards per attempt. Despite this, the Packers didn’t allow any passing touchdowns and recorded three sacks. Chicago also converted 56.2% of their third down attempts.

Green Bay’s defense gave up 391 total yards in the game. The Packers’ run defense was a bit of an issue, but they still managed to keep the Bears out of the endzone through the air, even though they allowed a 74.2% completion rate. The Packers also had a +4 advantage in the QB hit battle.

  • Free MoneyLine Prediction UNDER 48 (Bet Now)

49ers vs. Packers Prediction: Spread

Heading into week 12, the 49ers sit at 5-5, putting them 4th in the NFC West. Our projections give them a 26.8% chance of making the playoffs and an 18.8% chance of winning the division. Despite their record, they rank 7th in our NFL power rankings.

San Francisco has been favored in all of their games this season, but they are just 4-6 against the spread. They have an average scoring margin of +2.8 points per game and have failed to cover in two straight games, including a 20-17 loss to the Seahawks in week 11. The O/U line for that game was 49 points, with the teams combining for 37. The 49ers’ O/U record is 5-5 this season.

  • Spanning across their last three games, San Francisco have gone 2-1. This includes going 1-2 vs. the spread and posting an over-under mark of 1-2.
  • Through their last five road games, San Francisco has an ATS record of just 1-4. However, their overall record was 2-3 while averaging 24 points per game.

Heading into week 12, the Packers hold a 7-3 record, putting them 5th in our power rankings and giving them an 88.2% chance of making the playoffs. However, they are just 3rd in the NFC North, with a 1-2 division record. Green Bay has been better on the road (4-1) than at home (3-2) this season.

Against the spread, the Packers are 4-6 and have failed to cover in four straight games. In week 11, they narrowly beat the Bears 20-19 but didn’t cover as 6-point favorites. The O/U line was 41, and the teams combined for 39 points, putting the under on a two-game streak in Green Bay’s games.

  • Green Bay will look to keep things rolling as they have put together a mark of 2-1 over their past three games. This includes going 1-2 vs. the spread and posting an over-under mark of 0-2-1.
  • Across their five previous home games, Green Bay has an ATS mark of 2-3. Their straight up record in these matchups was 4-1 while averaging 26 points per game.
  • Free Spread Prediction 49ers +2.5 (Bet Now)

49ers vs. Packers Pick: 49ers Moneyline (+116)

Our projected score for this week 12 matchup between the 49ers and Packers is 26-19 in favor of the 49ers. With the point spread sitting at -2.5 in favor of the 49ers, we are picking them to not only win but also cover as road underdogs.

For an over/under pick, we like taking the under, with a projected combined score of 45 points and the O/U line at 48 points.

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