Chiefs vs 49ers Prediction & NFL Odds For Week 7

The 49ers are favored at -121 on the money line as they host the Chiefs at 4:25 ET on Sunday, October 20th at Levi’s Stadium in Santa Clara, CA. The Chiefs are +101 on the money line and +1.5 on the point spread. The game is being televised on FOX, and the over/under line is set at 46.5 points. Both teams need to add their current season records.

Prediction at a Glance for 49ers vs Chiefs

• We have the 49ers winning this one by a score of 23 to 22
• Even though we like the 49ers to win, our ATS pick is to take the Chiefs at +1.5
• We see this game finishing below the line of 46.5 points

Betting Odds & Lines for this Game

• Spread: Chiefs +1.5 | 49ers -1.5
• Total: 46.5
• MoneyLine: Chiefs +101 | 49ers -121

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

Chiefs vs. 49ers Prediction: MoneyLine

Heading into week 7, the Chiefs rank 8th in our offensive power rankings. They are 13th in the NFL in points per game (23.6) and 11th in yards per game (354.6). Kansas City ranks 9th in passing yards per game (236.8) and 16th in rushing yards per game (117.8). On 3rd down, they are converting 42.6% of the time, which is 8th in the league.

Patrick Mahomes threw for 331 yards in week 5, completing 28 of 39 passes, but he did not throw a touchdown and had one interception. JuJu Smith-Schuster led the team with 7 catches for 130 yards, and Kareem Hunt rushed for 102 yards on 27 carries. Rashee Rice, who had 110 receiving yards in week 3, is now on injured reserve.

Heading into week 7, the 49ers rank 6th in our offensive power rankings. They are 7th in the NFL in scoring, averaging 27 points per game, and 2nd in passing yards with 262 per game despite being 18th in pass attempts. San Francisco also ranks 3rd in rushing yards, averaging 158 per game on 31.3 attempts. They lead the NFL in red zone attempts but are 23rd in conversion percentage, scoring on 14.8% of their trips.

Brock Purdy bounced back in week 6, throwing for 255 yards and 3 touchdowns without an interception after a 2-pick game in week 5. The 49ers scored 13 points in the 2nd and 4th quarters against Seattle. Deebo Samuel Sr. led the team with 102 receiving yards, while Isaac Guerendo had 99 rushing yards on 10 carries.

• Free MoneyLine Prediction 49ers -121 (Bet Now)

Chiefs vs. 49ers Prediction: Total

In their 26-13 win over the Saints, the Chiefs’ defense held New Orleans to just 46 yards rushing on 15 attempts. The Chiefs’ secondary gave up 174 yards passing, with the Saints completing 20 passes. Despite allowing two passing touchdowns, they did force one interception. The Chiefs’ defense held the Saints to just a 3.1 yards per attempt average on the ground and limited them to 220 total yards.

On third downs, the Chiefs allowed the Saints to convert 40% of their chances. They recorded one sack and had three more quarterback hits than the Saints.

In their 36-24 win over the Seahawks, the 49ers’ defense allowed 306 passing yards on 30 completions. Despite this, they limited Seattle to 52 rushing yards on 20 attempts. The defense picked off two passes and held the Seahawks to just one touchdown through the air, with Seattle completing just 57.7% of their passes.

On 3rd downs, the 49ers allowed the Seahawks to convert 43.8% of their chances. Although they only managed one sack, the 49ers did win the quarterback hit battle and had a -1 disadvantage in tackles for loss.

• Free MoneyLine Prediction UNDER 46.5 (Bet Now)

Chiefs vs. 49ers Prediction: Spread

Heading into week 7, the Chiefs sit atop the AFC with a 5-0 record, giving them a 99.2% chance of making the playoffs and a 93.7% chance of winning the AFC West. In our NFL power rankings, Kansas City is 3rd. So far, they are 3-1-1 against the spread, having been favored in all of their games. In week 5, they covered the spread in a 26-13 win over the Saints, but the 39 combined points fell short of the 43-point line, marking the third straight game in which the under has hit in KC’s games.

In week 4, the Chiefs picked up a 17-10 road win over the Chargers, and in week 3, they beat the Falcons 22-17 in Atlanta. They also have home wins over the Bengals (26-25 in week 2) and Ravens (27-20 in week 1).

• Over their last three games, the Chiefs have gone 3-0 straight up. In these games, they have a 2-0-1 record vs the spread and an over-under mark of 0-3.
• When looking at their past five road matchups, Kansas City has an ATS record of 4-0-1 while averaging 19 per game. The team went 5-0 overall in these games.

Heading into week 7, the 49ers sit at 3-3, but they still hold the top spot in the NFC West. After a disappointing home loss to the Cardinals in week 5, they bounced back with a 36-24 win over the Seahawks in week 6. San Francisco was favored by 3.5 points in that game and covered the spread, bringing their ATS record to 3-3. They’ve been favored in all of their games so far, and their average scoring margin is +5.3 points.

According to our power rankings, the 49ers are 4th in the NFL, and we give them a 62.7% chance of making the playoffs and a 57.5% chance of winning the NFC West. Their O/U record is 4-2, with their games averaging 48.7 points compared to an average line of 45.8.

• San Francisco will look to keep things rolling as they have put together a mark of 2-1 over their past three games. In these games, they have a 2-1 record vs the spread and an over-under mark of 2-1.
• Across the 49ers last five home games, the team averaged 25 points per game while allowing 21. Their record vs the spread in these contests was 2-3, while going 2-3 straight-up.

• Free Spread Prediction Chiefs +1.5 (Bet Now)

Chiefs vs. 49ers Pick: 49ers Moneyline (-121)

Our pick vs. the spread is to take the Chiefs to cover as road underdogs in this week seven matchup between the Chiefs and 49ers. The point spread lines have the 49ers as slight favorites at -1.5, and we have the Chiefs coming out on top by a score of 23-22.

As for an over/under pick, we like the under, with a projected combined score of 45 points and the O/U line sitting at 46.5 points.