White Sox vs Padres Prediction & MLB Odds For Sunday, September 22nd
Chicago and San Diego face off in an interleague matchup at 4:10 PM ET at PETCO Park in San Diego, CA. The forecast calls for scattered clouds, and the Padres are heavily favored on the money line (-310). The White Sox have a money line payout of +255, and they are 36-119 this season. Chicago is currently on a four-game losing streak, and they are 5th in the AL Central.
Sunday’s over/under line is at 7.5 runs, and Yu Darvish will be on the mound for the Padres. The White Sox are starting Sean Burke. San Diego is 2nd in the NL West, while the White Sox are +255.
Betting Odds & Lines for this Game
- Spread: White Sox 1.5 (+112) | Padres -1.5 (-136)
- Total: 7.5
- MoneyLine: White Sox +255 | Padres -310
All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)
White Sox vs. Padres Prediction: Moneyline
San Diego cruised to a 6-2 win over the White Sox in the most recent game of this series. The Padres had a huge 2nd inning, scoring two of their six runs. As for the White Sox, they scored their only two runs in the 4th. Heading into the game, the Padres were favored at -316 on the money line.
Martin Perez only went 5 1/3 innings for the Padres but gave up just one run and picked up the win. He finished the game with six strikeouts but issued three walks. On the other side, Chris Flexen had a rough outing for the White Sox, taking the loss after going five innings and giving up four earned runs.
Elias Diaz and David Peralta each homered for the Padres, while Xander Bogaerts scored twice and drove in two runs while going 1/4. Jackson Merrill also had a two-hit game and scored a run for San Diego’s offense.
With a record of 36-119, the White Sox are 5th in the AL Central and trail the Guardians by 53.5 games. The White Sox have dropped four straight games, and they are 3-7 over their last 10. So far, they have really struggled against other AL Central teams, going 8-41.
Chicago has been really bad on the road this year, putting together a mark of 16-61. At home, the White Sox are just 20-58. As the underdog, the White Sox are 31-116 this year and 5-3 when favored. Coming into today’s game, the White Sox have dropped four straight as the road underdog. So far, they have an overall series record of 7-41-2.
With an overall record of 89-66, the Padres are three games behind the Dodgers for the NL West lead. The Padres have won three straight games, and they have taken two straight in their series vs. the White Sox. So far, they are 30-15-6 in series this year.
At home, the Padres are 44-36 this season and 45-30 on the road. San Diego has been good as the favorite this year, going 59-42 and 30-24 as the underdog. Looking at their overall record, the Padres have been good, going 8-2 over their last 10 games.
White Sox vs. Padres Prediction: Over/Under
The Chicago White Sox have played in 108 games this season with an over/under line higher than 7.5 runs, which accounts for 69.7% of their games. Their average combined run total this season is 8.2 runs, and their over/under record is 65-81. When the line is set at 7.5 runs, their over/under record is 12-19.
Chicago’s offense has been one of the worst in the league this season, as they are last in home runs and are batting just .221 as a team. They are also last in on-base percentage and OPS. The White Sox are averaging just 3.1 runs per game, which is the worst mark in the league. So far, they have been just as bad at home as they have been on the road.
Andrew Vaughn and Andrew Benintendi are the team’s top home run hitters this season, but both are batting under .230. Vaughn comes into the game with a batting average of .246 and Benintendi is hitting .226. Lenyn Sosa has been hot of late, going 9/22 in his last six games, with two homers and four RBIs.
The San Diego Padres have played in 88 games this season with an over/under line set at 7.5 runs, and their record in those games is 24-25. The Padres have a combined run average of 8.9 runs per game this season, and their over/under record overall is 80-71. The average over/under line in their games this season is 8 runs per game.
San Diego comes into the game as the league’s top hitting team, with a batting average of .266. They are also one of the top home run hitting teams in the league and have done a great job of avoiding strikeouts this season. Overall, the Padres are averaging 4.7 runs per game, which is 8th in the league. The team’s on-base percentage of .327 is also 3rd in the league.
Over the team’s last eight games, both Jackson Merrill and Fernando Tatis Jr. have been swinging the bat well, with Merrill hitting .433 and Tatis Jr. batting .353 with three homers. Tatis Jr. is also on a 10-game hitting streak. Manny Machado has also been hot of late, going 11/34 in his last eight games with three homers and 10 RBIs.
White Sox vs. Padres Prediction: Spread
When the White Sox win, they tend to do so by a comfortable margin, as their average run differential in victories is +3.3. However, when they lose, they lose big, with an average run differential of -3.7. They have struggled to cover the run line this season, going 63-92 overall, including a 32-45 mark on the road. As underdogs, they are just 58-89 against the run line.
Sean Burke will be making his second start of the season for the White Sox, as he took a no-decision in his first appearance. In that outing, he went 5 innings, giving up 2 earned runs on 5 hits and 2 walks. He did strike out 5 batters and gave up 1 home run. Burke’s first start was at home, and he picked up the win, facing the Athletics.
San Diego has been a solid run line team this season, going 79-76 overall. They have been especially good on the road, where they are 47-28. As the underdog, they are 37-17 vs. the run line. Their average run margin in winning games is +3.6, while it is -3.5 in losses.
Yu Darvish gets the start for the Padres today and will be looking to build off his last outing, where he didn’t give up a run. Against the Astros on September 16th, he pitched 6 innings, picking up the win in the outing. Looking at his overall numbers, Darvish has made 14 starts, and his record for the season is 6-3. His ERA is 3.21, along with a WHIP of 1.11. Opposing batters are hitting .218 off Darvish this season. So far, he has turned in four quality starts and is averaging 8.36 strikeouts per nine innings.
White Sox vs. Padres Pick: Over 7.5 Runs -118
Our prediction for the White Sox vs. Padres game is to take the over, as we see the final score being 5-4 in favor of the Padres. However, with the payout for a Padres win being just -310, we recommend taking the over at -118.
Looking at the starting pitchers, we have Yu Darvish finishing with six strikeouts, which is good for fifth among all starters. As for Sean Burke, we have him finishing with five K’s, which has him 19th.
