Guardians vs Cardinals Prediction & MLB Odds For Sunday, September 22nd
Cleveland is starting Gavin Williams, while the Cardinals have Andre Pallante on the mound. First pitch from Busch Stadium is set for 2:15 PM ET. BSGL is carrying this game on TV.
The over/under line is currently at 7.5 runs, and the Guardians are favored on the money line, with their odds sitting at -108 compared to the Cardinals at -111. This game will be played in St. Louis, and the forecast calls for moderate rain.
Betting Odds & Lines for this Game
- Spread: Guardians -1.5 (+159) | Cardinals 1.5 (-199)
- Total: 7.5
- MoneyLine: Guardians -108 | Cardinals -111
All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)
Guardians vs. Cardinals Prediction: Moneyline
It was a low-scoring game in the most recent game of this Cardinals vs. Guardians series. St. Louis went into the matchup as +111 underdogs and squeaked out a 6-5 win. The Cardinals had a big 7th inning, scoring four of their six runs. As for the Guardians, they scored one run in the 5th and added four in the 8th.
Cleveland wasted a good outing from Matthew Boyd, as he gave up just two earned runs in four innings of work. Ryan Helsley got the save for the Cardinals out of the bullpen. Miles Mikolas pitched well for St. Louis, getting the win after going six innings and giving up one earned run.
Jose Ramirez hit the game’s only home run while going 2/4 with three RBIs, but it came in a losing effort. Ivan Herrera did a bit of everything for the Cardinals, going 2/3 with a homer and three RBIs.
Cleveland is on the road today vs. the Cardinals with an overall record of 90-66, which has them leading the AL Central by 7.5 games. The Guardians have gone 30-22 against other teams in the AL Central. So far, they have been good at home, going 48-28 and have gone 42-38 on the road.
The Guardians have been really good as the favorite this year, putting up a mark of 62-34. As the underdog, they are 28-32 this year. Cleveland has been good as the road favorite, going 21-13. So far, they have an overall series record of 28-15-6.
With a record of 78-77, the Cardinals are 3rd in the NL Central, trailing the Brewers by 10 games. St. Louis is 26-26 against other teams in the division. The Cardinals will host the Guardians today and are 43-37 at home this season.
St. Louis has won two straight games as the underdog, and they are 41-40 as the underdog overall. As the favorite, the Cardinals are an even 37-37 this season. They are 5-5 across their last 10 games and are 1-1 in their series vs. the Guardians.
Guardians vs. Cardinals Prediction: Over/Under
The Cleveland Guardians have played to a combined run average of 8.3 runs per game this season, but their over/under record is just 68-77. Their games have had an average over/under line of 8 runs, and their over/under record when the line is set at 7.5 runs is 18-21. Overall, 69.2% of their games have had higher over/under lines than 7.5 runs.
Jose Ramirez and Josh Naylor have been the Guardians’ top power threats this season, as Ramirez’s 37 homers is 6th in the league, and Naylor is 11th with 31 long balls. Ramirez’s 112 RBIs is 3rd in the MLB, while Naylor is 7th with 105 RBIs. Ramirez comes into the game batting .276, while Naylor is hitting .241.
Andres Gimenez has been hot of late for the Guardians, going 8/20 in his last five games with a homer and three RBIs. Lane Thomas and Steven Kwan are also on hitting streaks for the Guardians, with Thomas having a three-game streak and Kwan a four-game streak.
The St. Louis Cardinals are home today against the Cleveland Guardians, and the over/under line for the game is set at 7.5 runs. The Cardinals have played 113 games this season with over/under lines higher than 7.5 runs, which is 72.9% of their games. Their combined run average this season is 8.6 runs per game, and their over/under record for the season is 72-79. When the over/under line has been set at 7.5 runs, their record is 13-22.
The Cardinals offense has been pretty average this season, as they are 10th in team batting average and are averaging 4.1 runs per game (25th in the league). They have been a bit better at home, averaging 4.2 runs per game. St. Louis is also 20th in home runs and 19th in OPS. As a team, they are averaging 8 strikeouts per game and are 21st in walks.
St. Louis’s top home run hitters this season are Alec Burleson and Paul Goldschmidt, who each have 21 homers. Brendan Donovan is batting .273 this season and has 13 homers. Over his last seven games, Jordan Walker has gone 6/24 with two homers and seven RBIs.
Guardians vs. Cardinals Prediction: Spread
On the road, the Guardians have been a good bet against the run line, going 42-38. They have a positive run differential away from home, averaging 0.4 more runs per game than their opponents. They have been a better run line bet as the underdog, going 35-25, compared to 44-52 as the favorite.
Gavin Williams is looking to bounce back from a rough outing vs. the Twins, where he took the loss and gave up two earned runs in five innings of work. In that start, he gave up two homers. Williams has a record of 3-10 and an ERA of 5.12. Looking at his WHIP, it is currently 1.39. Out of his 15 starts, Williams has turned in three quality starts and is averaging 9.73 strikeouts per nine innings. For the season, he has allowed a total of seven homers. Williams’ ERA on the road is 11.2 compared to 6.98 at home.
When the Cardinals win, they win big. Their average run differential in wins is +2.7, while in losses it’s -3.5. Their run line record as the underdog is 53-28, and they have won three in a row against the run line as the underdog.
Right-hander Andre Pallante gets the start for the Cardinals today as he faces off against the Guardians. Pallante has made 18 starts this season and has a record of 7-8. His ERA for the season is 3.87, along with a WHIP of 1.35. In his 27 appearances, Pallante has turned in six quality starts. Looking back at his most recent outing, Pallante was terrific, going seven innings and picking up the win. In that outing, he didn’t give up a run and allowed just four hits. Before that, he had lost three straight starts.
Guardians vs. Cardinals Pick: Cardinals ML -111
Getting the Cardinals at -111 on the money line is a great value pick for this game. We actually have the Cardinals winning this one 6-5, so there is also some value on the over, as the line is currently sitting at 7.5 runs.
Looking at the starting pitcher’s, we have Andre Pallante finishing with four strikeouts compared to Gavin Williams with six. However, we have Pallante finishing with a higher ERA, and we actually have Williams finishing with the fourth-fewest hits allowed among starters today.
