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49ers vs Vikings Prediction & NFL Odds For Week 2

The 49ers are favored on the road as they take on the Vikings at 1:00 ET on Sunday, September 15th at U.S. Bank Stadium in Minneapolis. The game is being televised on CBS. The 49ers’ money line odds are -267, while the Vikings’ odds are +216. The 49ers are favored by -6 points, and the over/under line is set at 45.5 points.

Prediction at a Glance for Vikings vs 49ers

  • We have the Vikings winning this one by a score of 23 to 20
  • Not only do we have the Vikings winning straight-up, we have them covering the spread at +6
  • We see this game finishing below the line of 45.5 points

Betting Odds & Lines for this Game

  • Spread: 49ers -6 | Vikings +6
  • Total: 45.5
  • MoneyLine: 49ers -267 | Vikings +216

All Odds are courtesy of (BetMGM | DraftKings | Fanduel | BetRivers)

49ers vs. Vikings Prediction: MoneyLine

The 49ers’ offense picked up 24 first downs in their 32-19 win over the Jets, racking up 180 rushing yards on 38 attempts. They finished with 221 yards passing and were 46.2% on third down. Brock Purdy threw for 231 yards (19/29), and Jordan Mason had a big game on the ground, rushing for 147 yards and averaging 5.2 yards per attempt.

Jauan Jennings led the team with 64 receiving yards. The offense didn’t find the endzone through the air, and Purdy was sacked three times. However, the ground game was effective, with Mason breaking off a 24-yard run and scoring one rushing touchdown.

The Vikings’ offense put up 201 yards through the air in their 28-6 win over the Giants, with Sam Darnold completing 19 of 24 passes for 208 yards and two touchdowns. Minnesota finished with 17 first downs and 111 yards on the ground across 26 attempts. Darnold threw one interception, and the team struggled on third down, converting only 30% of their chances.

Justin Jefferson led the team with 59 yards receiving, including a 44-yard touchdown catch. Aaron Jones was the top rusher with 94 yards on 14 carries, including a touchdown and a 19-yard run.

  • Free MoneyLine Prediction Vikings +216 (Bet Now)

49ers vs. Vikings Prediction: Total

Even though the 49ers’ defense allowed two passing touchdowns in their most recent game against the Jets, they came away with an interception and limited New York to just 198 passing yards. San Francisco defended the run well, as the Jets managed only 68 rushing yards on 19 attempts. The 49ers’ defense held the Jets to a 60% third-down conversion rate and allowed just one sack.

The 49ers’ defense was also tough to move the ball against, as they held the Jets to 266 total yards in their 32-19 win. Despite allowing two passing touchdowns, the 49ers’ defense forced the Jets to sustain long drives, as they had a 65.5% completion percentage on their passes.

Minnesota’s defense was dominant in their 28-6 win over the Giants, allowing just 166 passing yards and forcing two interceptions. They held New York to 240 total yards and limited them to 3.5 yards per attempt on 21 rushes. The Vikings also didn’t allow a passing touchdown, and the Giants converted only 38.9% of their third down attempts.

The Vikings’ pass rush was fierce, recording five sacks and generating 10 more quarterback hits than the Giants. Minnesota’s secondary defended well, holding the Giants to a 52.4% completion percentage.

  • Free MoneyLine Prediction UNDER 45.5 (Bet Now)

49ers vs. Vikings Prediction: Spread

San Francisco is now 1-0 after their 32-19 win over the Jets. The 49ers were favored by -3.5 and with their 13-point win, they covered the spread. The combined 51 points surpassed the over/under line of 43.5 points. The 49ers fell behind early, with the Jets scoring a touchdown in the first quarter, but they took control of the game with a big 2nd quarter.

Jake Moody’s field goal put the 49ers ahead in the 1st quarter, and in the 2nd quarter, Brock Purdy found Jauan Jennings for a touchdown, and Deebo Samuel added another touchdown to give the 49ers a 19-7 lead at halftime. In the 3rd quarter, both teams added touchdowns, and the 49ers closed out the game with a 6-yard touchdown pass from Purdy to Samuel in the 4th quarter.

  • Through their last three games, the 49ers have a record of 2-1. Across these games, they have put together an ATS mark of 1-2 as well as an over-under record of 2-0-1.
  • Across their last five road contests, San Francisco has been good against the spread posting a mark of 4-1. Their overall mark in these games was 4-1, while averaging 33 points per game.

The Vikings’ 28-6 win over the Giants improved their record to 1-0. Minnesota, who was on the road for this one, took the lead early and never looked back. After Minnesota trailed 3-0 early, Aaron Jones’ 3-yard touchdown put the Vikings up 7-3 after the 1st quarter. From there, Minnesota scored unanswered points until the Giants added a field goal in the 3rd quarter.

At halftime, the Vikings led 14-3 after a 44-yard touchdown pass from Sam Darnold to Justin Jefferson. In the 3rd quarter, Darnold found Johnny Mundt for another touchdown. The Vikings’ defense kept the Giants out of the endzone until late in the 3rd quarter when they added a field goal.

  • Through their last three regular season contests, Minnesota has a record of 0-3. In these contests, the team went just 0-3 against the spread, while going 2-1 on the over-under.
  • Minnesota has a 2-3 record in their last five home games. In this stretch, they averaged 19 points per game while allowing 16. The team also performed well vs the spread at 2-1-2.
  • Free Spread Prediction Vikings +6 (Bet Now)

49ers vs. Vikings Pick: Vikings Moneyline (+216)

Our prediction for this week two matchup between the 49ers and Vikings is to take the Vikings to cover the spread. Right now, the point spread lines have the Vikings at -6, and we have them not only covering but winning by a score of 20-18. With the point spread being +6 in favor of the Vikings, they are our pick vs. the spread.

As for the over/under, we have this one finishing with 38 combined points, which is well below the O/U line of 45.5. So, if you are looking to make a play on the over/under, we’d recommend taking the under.

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